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Chalcone hybrids and their antimalarial activity
Archiv der Pharmazie ( IF 4.3 ) Pub Date : 2020-04-01 , DOI: 10.1002/ardp.201900350 Peng Cheng 1 , Linlin Yang 2 , Xiaodan Huang 1 , Xuejun Wang 3 , Maoqing Gong 1
Archiv der Pharmazie ( IF 4.3 ) Pub Date : 2020-04-01 , DOI: 10.1002/ardp.201900350 Peng Cheng 1 , Linlin Yang 2 , Xiaodan Huang 1 , Xuejun Wang 3 , Maoqing Gong 1
Affiliation
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Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus Plasmodium, places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug‐resistant malaria, creating an urgent need to develop novel antimalarial agents. Chalcone derivatives are ubiquitous in nature and have become indispensable units in medicinal chemistry applications due to their diverse biological profiles. Many chalcone derivatives demonstrate potential in vitro and in vivo antimalarial activity, so chalcone could be a useful template for the development of novel antimalarial agents. This review covers the recent development of chalcone hybrids as antimalarial agents. The critical aspects of the design and structure–activity relationship of these compounds are also discussed.
中文翻译：
查耳酮杂种及其抗疟活性
疟疾是由疟原虫属引起的最引人注目的重新出现的传染病之一，给全球医疗保健系统带来了巨大的负担。控制和根除疟疾的一个主要挑战是日益普遍的耐药性疟疾的不断出现，迫切需要开发新型抗疟药物。查尔酮衍生物在自然界中无处不在，由于其多样化的生物学特征，已成为药物化学应用中不可或缺的单位。许多查尔酮衍生物显示出潜在的体外和体内抗疟活性，因此查尔酮可能是开发新型抗疟药的有用模板。这篇综述涵盖了查耳酮杂交物作为抗疟药的最新发展。
更新日期：2020-04-01
中文翻译：
查耳酮杂种及其抗疟活性
疟疾是由疟原虫属引起的最引人注目的重新出现的传染病之一，给全球医疗保健系统带来了巨大的负担。控制和根除疟疾的一个主要挑战是日益普遍的耐药性疟疾的不断出现，迫切需要开发新型抗疟药物。查尔酮衍生物在自然界中无处不在，由于其多样化的生物学特征，已成为药物化学应用中不可或缺的单位。许多查尔酮衍生物显示出潜在的体外和体内抗疟活性，因此查尔酮可能是开发新型抗疟药的有用模板。这篇综述涵盖了查耳酮杂交物作为抗疟药的最新发展。
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