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Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production.
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.chom.2020.01.006 Edward C Deehan 1 , Chen Yang 1 , Maria Elisa Perez-Muñoz 1 , Nguyen K Nguyen 1 , Christopher C Cheng 2 , Lucila Triador 3 , Zhengxiao Zhang 3 , Jeffrey A Bakal 4 , Jens Walter 5
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.chom.2020.01.006 Edward C Deehan 1 , Chen Yang 1 , Maria Elisa Perez-Muñoz 1 , Nguyen K Nguyen 1 , Christopher C Cheng 2 , Lucila Triador 3 , Zhengxiao Zhang 3 , Jeffrey A Bakal 4 , Jens Walter 5
Affiliation
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Dietary fibers (DFs) impact the gut microbiome in ways often considered beneficial. However, it is unknown if precise and predictable manipulations of the gut microbiota, and especially its metabolic activity, can be achieved through DFs with discrete chemical structures. Using a dose-response trial with three type-IV resistant starches (RS4s) in healthy humans, we found that crystalline and phosphate cross-linked starch structures induce divergent and highly specific effects on microbiome composition that are linked to directed shifts in the output of either propionate or butyrate. The dominant RS4-induced effects were remarkably consistent within treatment groups, dose-dependent plateauing at 35 g/day, and can be explained by substrate-specific binding and utilization of the RS4s by bacterial taxa with different pathways for starch metabolism. Overall, these findings support the potential of using discrete DF structures to achieve targeted manipulations of the gut microbiome and its metabolic functions relevant to health.
中文翻译：
具有离散膳食纤维结构的精确微生物组调节指导短链脂肪酸的生产。
膳食纤维（DFs）以通常认为有益的方式影响肠道微生物组。但是，尚不清楚是否可以通过具有离散化学结构的DF实现对肠道菌群的精确和可预测的操纵，尤其是其代谢活性。通过在健康人类中对三种IV型抗性淀粉（RS4）进行剂量反应试验，我们发现结晶和磷酸交联的淀粉结构对微生物组组成诱导了发散性和高度特异性的作用，这些作用与微生物输出的定向变化有关。丙酸或丁酸。在治疗组中，主要的RS4诱导的作用非常一致，剂量依赖性稳定在35 g /天，这可以通过底物特异性结合和细菌分类单元利用淀粉代谢不同途径的RS4来解释。
更新日期：2020-01-31
中文翻译：
具有离散膳食纤维结构的精确微生物组调节指导短链脂肪酸的生产。
膳食纤维（DFs）以通常认为有益的方式影响肠道微生物组。但是，尚不清楚是否可以通过具有离散化学结构的DF实现对肠道菌群的精确和可预测的操纵，尤其是其代谢活性。通过在健康人类中对三种IV型抗性淀粉（RS4）进行剂量反应试验，我们发现结晶和磷酸交联的淀粉结构对微生物组组成诱导了发散性和高度特异性的作用，这些作用与微生物输出的定向变化有关。丙酸或丁酸。在治疗组中，主要的RS4诱导的作用非常一致，剂量依赖性稳定在35 g /天，这可以通过底物特异性结合和细菌分类单元利用淀粉代谢不同途径的RS4来解释。
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