The positioning of nuclei within the cell is a dynamic process that depends on the cell's fate and developmental stage and that is adjusted for optimal cell function. This is especially true in skeletal muscle cells, which contain hundreds of myonuclei distributed evenly along the periphery of the muscle cell. Mispositioned myonuclei are often associated with muscle dysfunction and disease. Different mechanisms governing myonuclear positioning are now emerging, with several of the new genes implicated in nuclear movement linked to human muscle disease. Here we discuss the recent advances in myonuclear positioning and its implications for muscle size and function from the view of Drosophila. Additionally, we highlight similarities and differences to mammalian systems and provide connections to human muscle disease.

中文翻译：

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入位：肌肉细胞的核运动。

细胞核在细胞内的定位是一个动态过程，取决于细胞的命运和发育​​阶段，并针对最佳细胞功能进行了调整。在骨骼肌细胞中尤其如此，骨骼肌细胞中包含数百个沿肌细胞外围均匀分布的肌核。肌核位置不正确通常与肌肉功能障碍和疾病有关。现在正在出现控制肌核定位的不同机制，其中涉及与人类肌肉疾病有关的核运动的一些新基因。在这里，我们从果蝇的角度讨论了肌核定位的最新进展及其对肌肉大小和功能的影响。此外，我们强调了与哺乳动物系统的异同，并提供了与人类肌肉疾病的联系。