The systemic administration of low reserpine (RES) doses (0.1-1.0 mg/kg) has been proposed as a valuable rat model for the study of non-motor symptoms of Parkinson's disease (PD). Here, we investigated the temporal-dependent effects of RES (1 mg/kg, s.c.) on short-term memory and locomotion, as well as, the levels of dopamine, serotonin and its metabolites in the striatum, hippocampus and prefrontal cortex at 3, 24 or 72 h after RES administration. RES administrations resulted in social and object recognition memory impairment and increased dopamine turnover in the striatum, without changes in the rat spontaneous locomotor activity, 3 h after RES administration. Altogether, these results provide new insights for the use of RES administration as an experimental design for the study of PD non-motor symptoms in rats.

中文翻译：

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利血平给药后大鼠神经化学和认知功能障碍的时间发展。

有人建议低剂量利血平（RES）（0.1-1.0 mg / kg）的全身给药作为研究帕金森氏病（PD）的非运动性症状的有价值的大鼠模型。在这里，我们研究了RES（1 mg / kg，sc）对短期记忆和运动以及纹状体，海马和前额叶皮层中多巴胺，5-羟色胺及其代谢物的水平在3点时的时间依赖性影响RES给药后24小时或72小时。RES给药后3小时，RES给药导致社交和物体识别记忆受损，纹状体中多巴胺更新增加，而大鼠自发运动能力没有变化。总之，这些结果为使用RES给药作为研究大鼠PD非运动症状的实验设计提供了新的见解。