BACKGROUND Depression is a debilitating condition with a profound influence on quality of life for millions of people globally. Physical exercise has been broadly recognized for its therapeutic effects on depression, but the mechanisms that underlie its benefits remain unknown. In the study, we investigated whether the physical exercise of could be a protection from stress-induced depression and its impact on the brain activity of Regional Homogeneity (ReHo) in mice. METHODS Adult male C57BL/6 mice were assigned to one of the following groups: control group; exercise group, 2 h/day in a running wheel apparatus; chronic unpredictable mild stress (CUMS) group; CUMS + exercise group. rs-fMRI was applied to detect the changes of regional spontaneous activity. RESULTS Firstly, CUMS-induced depressive behavior was significantly reduced by exercise. Base on the ReHo analysis, disorders of the regional spontaneous activity in the brain of CUMS mice, primarily in the limbic system, especially in the hippocampus and PFC, motor cortex, sensory cortex, visual cortex were found. While exercise remarkably prevented the CUMS-induced chaos of brain activity in parts of the above regions, such as cortex, hippocampus and corpus callosum. These results suggested physical exercise could prevent the dysfunction of mood-regulating circuit in CUMS model. Furthermore, exercise improved skeletal muscle PGC-1a and hippocampal BDNF levels in stress mice, and reduced IDO1 in skeletal muscle. CONCLUSIONS These results suggested that exercise prevented CUMS induced depressive behaviors and brain regional spontaneous activity in mice, accompanied with the adjustment of skeletal muscle PGC-1a/IDO1 signals and hippocampal function.

中文翻译：

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体育锻炼可纠正CUMS诱导的小鼠异常区域同质性，并伴随骨骼肌PGC-1a / IDO1信号和海马功能的调节。

背景技术抑郁症是使世界上数百万人的生活质量受到深远影响的令人衰弱的状况。体育锻炼对抑郁症的治疗作用已得到广泛认可，但其益处的机制尚不清楚。在这项研究中，我们研究了体育锻炼是否可以预防压力诱发的抑郁症及其对小鼠区域同质性（ReHo）脑活动的影响。方法将成年雄性C57BL / 6小鼠分为以下一组：对照组；对照组。运动组，每天2小时在轮式运动器械中；慢性不可预测的轻度应激（CUMS）组；CUMS +运动组。rs-fMRI用于检测区域自发活动的变化。结果首先，通过运动可以显着降低CUMS引起的抑郁行为。根据ReHo分析，发现CUMS小鼠大脑主要是边缘系统，尤其是海马和PFC，运动皮层，感觉皮层，视觉皮层的区域自发活动异常。尽管运动显着阻止了CUMS在上述区域的某些区域（如皮质，海马和call体）引起的大脑活动混乱。这些结果表明体育锻炼可以预防CUMS模型中的情绪调节电路功能障碍。此外，运动改善了应激小鼠的骨骼肌PGC-1a和海马BDNF水平，并降低了骨骼肌中的IDO1。结论这些结果表明，运动可预防CUMS诱发小鼠的抑郁行为和脑区域自发活动，