Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.

尽管已有报道关于通过使用神经元分化或控制微环境将间充质干细胞（MSCs）用于神经退行性疾病的移植，但传统的外科移植方法（如实质性或静脉内注射）存在局限性，例如继发性损伤等。大脑，感染以及目标部位干细胞存活率低。聚焦超声（FUS）治疗是一种用于治疗包括神经退行性疾病在内的脑部疾病的新兴方法。已经对FUS治疗的各种生物学效应进行了研究。因此，现在的目标是通过利用FUS的优势来提高MSC的传递效率和功能。在这个研究中，