BACKGROUND We aimed to develop the age- and sex-specific reference values for lipid profile of Iranian pediatric population. METHODS Fasting lipid profiles of 3843 participants, aged 7 to 18 years, were extracted from a surveillance survey on Iranian children and adolescents living in 30 provinces across the country. RESULTS The mean (SD) age of participants was 12.3(3.1) years, and 52.3% of them were boys. Significant differences were observed between genders comparing the levels of triglyceride (TG) (P = 0.04), total cholesterol (TC) (P = 0.02), low-density lipoprotein- cholesterol (LDL-C) (P = 0.01), and non-high-density lipoprotein cholesterol (non-HDL-C) (P = 0.03). In both genders, TG levels increased with age in the 75th and higher percentiles. Among boys, TC showed a decreasing trend at all percentiles and all age groups. In girls, TC levels increased with age at all percentiles except for the 75th and 90th percentiles. Among boys, the levels of LDL-C and HDL-C decreased with age in all percentiles. However, LDL-C and HDL-C concentrations increased up to the 50th percentile in girls and then decreased with age. The non-HDL-C level decreased in the 50th and higher percentiles among boys and in the 90th and 95th percentiles among girls. The TG/HDL-C ratio increased with age at all percentiles in boys. In girls, TG/HDL-C ratio increased with age in the 50th and higher percentiles. CONCLUSIONS Based on the observed differences, it seems necessary to determine age- and sex-specific cut-off values for lipid parameters of children and adolescents in different populations.

中文翻译：

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伊朗儿童和青少年的血脂参考值：CASPIAN-V 研究。

背景我们的目的是为伊朗儿科人群制定年龄和性别特定的血脂参考值。方法 通过对居住在全国 30 个省份的伊朗儿童和青少年进行的监测调查，提取了 3843 名 7 至 18 岁参与者的空腹血脂谱。结果 参与者的平均年龄（SD）为12.3（3.1）岁，其中52.3%为男孩。比较甘油三酯（TG）（P = 0.04）、总胆固醇（TC）（P = 0.02）、低密度脂蛋白胆固醇（LDL-C）（P = 0.01）和非胆固醇水平，性别之间存在显着差异。 -高密度脂蛋白胆固醇（非HDL-C）（P = 0.03）。无论性别，在第 75 个百分位及更高的百分位数中，TG 水平都随着年龄的增长而增加。在男孩中，TC 在所有百分位数和所有年龄组中均呈下降趋势。在女孩中，除 75 和 90 百分位数外，所有百分位数的 TC 水平都随着年龄的增长而增加。在男孩中，所有百分位数的 LDL-C 和 HDL-C 水平都随着年龄的增长而下降。然而，女孩的 LDL-C 和 HDL-C 浓度最高可达第 50 个百分位数，然后随着年龄的增长而下降。男孩中第 50 个百分位数及以上的非 HDL-C 水平下降，而女孩中第 90 个百分位数和第 95 个百分位数的非 HDL-C 水平下降。男孩的所有百分位数的 TG/HDL-C 比率均随年龄增加而增加。在女孩中，TG/HDL-C 比率在第 50 个百分位及更高百分位时随着年龄的增长而增加。结论 根据观察到的差异，似乎有必要确定不同人群中儿童和青少年血脂参数的年龄和性别特异性临界值。