当前位置: X-MOL 学术J. Nanobiotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biodegradable polymer nanocomposites for ligament/tendon tissue engineering.
Journal of Nanobiotechnology ( IF 10.2 ) Pub Date : 2020-01-30 , DOI: 10.1186/s12951-019-0556-1
Magda Silva 1, 2, 3, 4 , Fernando N Ferreira 4 , Natália M Alves 1, 2 , Maria C Paiva 3
Affiliation  

Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto- or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed.

中文翻译:

用于韧带/肌腱组织工程的可生物降解的聚合物纳米复合材料。

韧带和肌腱是血管组织较弱且再生能力有限的纤维组织。当前,韧带/肌腱损伤经常需要使用自体或同种异体移植的外科手术,这存在一些局限性。这些不足之处以及对经济和健康的重大影响促使组织工程学方法的发展。基于这种材料的几种天然和合成的可生物降解的聚合物以及复合材料,共混物和杂化物已被用于生产肌腱和韧带支架。考虑到天然组织的复杂结构,基于纤维的支架的生产已成为腱/韧带组织工程的首选选择。静电纺丝和几种纺织方法,如加捻,编织和编织已被用于生产这些支架。这篇综述着重于基于不同生物可降解聚合物的肌腱/韧带支架的制备进展。概述了几个例子,并讨论了它们的处理方法以及生物学和机械性能。
更新日期:2020-04-22
down
wechat
bug