BACKGROUND Investigation of the myocardial strain characteristics of the left ventricular non-compaction (LVNC) phenotype with cardiovascular magnetic resonance (CMR) feature tracking. METHODS CMR cine balanced steady-state free precession data sets of 59 retrospectively identified LVNC phenotype patients (40 years, IQR: 28-50 years; 51% male) and 36 healthy subjects (39 years, IQR: 30-47 years; 44% male) were evaluated for LV volumes, systolic function and mass. Hypertrabeculation in patients and healthy subjects was evaluated against established CMR diagnostic criteria. Global circumferential strain (GCS), global radial strain (GRS) and global longitudinal strain (GLS) were evaluated with feature-tracking software. Subgroup analyses were performed in patients (n = 25) and healthy subjects (n = 34) with normal LV volumetrics, and with healthy subjects (n = 18) meeting at least one LVNC diagnostic criteria. RESULTS All LVNC phenotype patients, as well as a significant proportion of healthy subjects, met morphology-based CMR diagnostic criteria: non-compacted (NC): compacted myocardial diameter ratio > 2.3 (100% vs. 19.4%), NC mass > 20% (100% vs. 44.4%) and > 25% (100% vs. 13.9%), and NC mass indexed to body surface area > 15 g/m2 (100% vs. 41.7%). LVNC phenotype patients demonstrated reduced GRS (26.4% vs. 37.1%; p < 0.001), GCS (- 16.5% vs. -20.5%; p < 0.001) and GLS (- 14.6% vs. -17.1%; p < 0.001) compared to healthy subjects, with statistically significant differences persisting on subgroup comparisons of LVNC phenotype patients with healthy subjects meeting diagnostic criteria. GCS also demonstrated independent and incremental diagnostic value beyond each of the morphology-based CMR diagnostic criteria. CONCLUSIONS LVNC phenotype patients demonstrate impaired strain by CMR feature tracking, also present on comparison of subjects with normal LV volumetrics meeting diagnostic criteria. The high proportion of healthy subjects meeting morphology-based CMR diagnostic criteria emphasizes the important potential complementary diagnostic value of strain in differentiating LVNC from physiologic hypertrabeculation.

中文翻译：

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基于心血管磁共振的左心室非致密性心肌病的诊断：电影bSSFP株分析的影响。

背景研究具有心血管磁共振（CMR）特征跟踪的左心室非致密（LVNC）表型的心肌应变特征。方法CMR cine平衡稳态自由进动数据集包括59例回顾性鉴定的LVNC表型患者（40岁，IQR：28-50岁；男性51％）和36名健康受试者（39岁，IQR：30-47岁； 44％）男性）评估左室容量，收缩功能和质量。根据既定的CMR诊断标准评估患者和健康受试者的超小梁。使用特征跟踪软件评估了整体圆周应变（GCS），整体径向应变（GRS）和整体纵向应变（GLS）。亚组分析是在左室容积正常的患者（n = 25）和健康受试者（n = 34）中进行的，且健康受试者（n = 18）至少满足一项LVNC诊断标准。结果所有LVNC表型患者以及相当比例的健康受试者均符合基于形态学的CMR诊断标准：非紧凑型（NC）：紧凑型心肌直径比> 2.3（100％比19.4％），NC质量> 20 ％（100％vs. 44.4％）和> 25％（100％vs. 13.9％），并且NC质量指数大于15 g / m2（100％vs. 41.7％）。LVNC表型患者显示GRS（26.4％vs. 37.1％; p <0.001），GCS（-16.5％vs.-20.5％; p <0.001）和GLS（-14.6％vs.-17.1％; p <0.001）降低与健康受试者相比，LVNC表型患者与符合诊断标准的健康受试者的亚组比较仍存在统计学上的显着差异。GCS还证明了超越基于形态学的CMR诊断标准的独立和递增的诊断价值。结论LVNC表型患者通过CMR特征追踪显示出劳损受损，也出现在具有符合诊断标准的正常LV容量的受试者的比较中。符合基于形态学CMR诊断标准的健康受试者比例很高，强调了菌株在区分LVNC和生理性超小梁形成中潜在的重要补充诊断价值。