People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer diagnosis in PLHIV enrolled in European and North American HIV cohorts starting antiretroviral therapy (ART) 1996-2015, aged ≥16 years, and subsequently diagnosed with cancer. Cancers were grouped: ADMs, viral NADMs and nonviral NADMs. We calculated cause-specific mortality rates (MR) after diagnosis of specific cancers and compared 5-year survival with the UK and France general populations. Among 83,856 PLHIV there were 4,436 cancer diagnoses. Of 603 deaths after ADM diagnosis, 292 (48%) were due to an ADM. There were 467/847 (55%) and 74/189 (39%) deaths that were due to an NADM after nonviral and viral NADM diagnoses, respectively. MR were higher for diagnoses between 1996 and 2005 versus 2006-2015: ADMs 102 (95% CI 92-113) per 1,000 years versus 88 (78-100), viral NADMs 134 (106-169) versus 111 (93-133) and nonviral NADMs 264 (232-300) versus 226 (206-248). Estimated 5-year survival for PLHIV diagnosed with liver (29% [19-39%]), lung (18% [13-23%]) and cervical (75% [63-84%]) cancer was similar to general populations. Survival after Hodgkin's lymphoma diagnosis was lower in PLHIV (75% [67-81%]). Among ART-treated PLHIV diagnosed with cancer, MR and causes of death varied by cancer type, with mortality highest for liver and lung cancers. Deaths within 5 years of NADM diagnoses were more likely to be from cancer than AIDS.

中文翻译：

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HIV 阳性患者诊断为癌症后的特定原因死亡率：队列研究的协作分析。

艾滋病毒感染者 (PLHIV) 比一般人群更有可能患上艾滋病定义的恶性肿瘤 (ADM) 和几种非 ADM (NADM)。缺乏关于 PLHIV 中癌症诊断后的生存结果和特定原因死亡率的信息。我们调查了在 1996-2015 年开始抗逆转录病毒治疗 (ART) 的欧洲和北美 HIV 队列、年龄≥16 岁、随后被诊断出患有癌症的 PLHIV 在癌症诊断后 5 年内的死亡原因。癌症被分组：ADMs、病毒性NADMs和非病毒性NADMs。我们计算了诊断出特定癌症后的病因特异性死亡率 (MR)，并将 5 年生存率与英国和法国的一般人群进行了比较。在 83,856 名 PLHIV 感染者中，有 4,436 人被诊断为癌症。在 ADM 诊断后的 603 例死亡中，292 例 (48%) 是由于 ADM。在非病毒性和病毒性 NADM 诊断后，分别有 467/847 (55%) 和 74/189 (39%) 人死于 NADM。与 2006-2015 年相比，1996 年至 2005 年间诊断的 MR 更高：每 1000 年 ADM 102 (95% CI 92-113) 与 88 (78-​​100)，病毒性 NADM 134 (106-169) 与 11333 ()和非病毒 NADM 264 (232-300) 与 226 (206-248)。被诊断为肝癌 (29% [19-39%])、肺癌 (18% [13-23%]) 和宫颈癌 (75% [63-84%]) 的 PLHIV 的估计 5 年生存率与一般人群相似. 霍奇金淋巴瘤诊断后的存活率在 PLHIV 中较低（75% [67-81%]）。在接受 ART 治疗的被诊断为癌症的 PLHIV 中，MR 和死亡原因因癌症类型而异，肝癌和肺癌的死亡率最高。NADM 诊断后 5 年内的死亡更可能来自癌症而不是艾滋病。