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Evaluation of cytotoxicity in vitro and properties of polysiloxane-based polyurethane/lignin elastomers
Reactive & Functional Polymers ( IF 4.5 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.reactfunctpolym.2020.104514
Chang-an Xu , Guokang Chen , Zhiyou Tan , Zhuorong Hu , Zhencai Qu , Qian Zhang , Maoping Lu , Kun Wu , Mangeng Lu , Liyan Liang

Polysiloxane-based polyurethane/lignin elastomers are synthesized via pre-polymerization. Isophorone diisocyanate (IPDI) reacts with polycarbonate (PCDL) and polydimethylsiloxane (PDMS) polyol to produce a linear thermoplastic elastomer. Lignin is added to the matrix of the polyurethane, where lignin not only acts as a crosslinking agent but also as filler. The effects of polysiloxane-based polyurethane/lignin elastomers on thermal properties, mechanical properties, surface hydrophobicity, and cytotoxicity in vitro are investigated. The heat resistance, surface hydrophobicity and mechanical strength of the materials are improved, and a decreased cytotoxic behavior against HeLa cells by MTT assay is observed, which should be attributed to the semi-interpenetrating network structure and low toxicity of lignin, respectively. With the addition of 1 wt% of lignin, cell viability increases to 65.2%, mechanical strength increases to 17.1 Mpa and contact angle increases to 108.2°.



中文翻译:

聚硅氧烷基聚氨酯/木质素弹性体的体外细胞毒性和性能评估

通过预聚合合成基于聚硅氧烷的聚氨酯/木质素弹性体。异佛尔酮二异氰酸酯(IPDI)与聚碳酸酯(PCDL)和聚二甲基硅氧烷(PDMS)多元醇反应生成线性热塑性弹性体。木质素被添加到聚氨酯的基质中,其中木质素不仅充当交联剂而且充当填充剂。研究了聚硅氧烷基聚氨酯/木质素弹性体对体外热学性能,机械性能,表面疏水性和细胞毒性的影响。材料的耐热性,表面疏水性和机械强度得到改善,并且通过MTT测定观察到对HeLa细胞的细胞毒性行为降低,这分别应归因于木质素的半互穿网络结构和低毒性。

更新日期:2020-01-30
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