Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8+ T cells. We discuss the dynamic features of post-transcriptional control during CD8+ T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses.

中文翻译：

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控制CD8 + T细胞稳态和效应子功能的动态转录后事件。

针对感染和肿瘤的有效T细胞反应需要迅速大量生产细胞因子，趋化因子和细胞毒性分子。这些效应分子的产生取决于基因表达的快速变化，该变化由细胞内在信号和环境提示决定。在这里，我们回顾了我们目前对基因特异性调控网络的理解，这些基因定义了CD8 + T细胞中细胞因子产生的大小和时间。我们讨论了CD8 + T细胞稳态和激活过程中转录后控制的动态特征，并着重于细胞信号传导和RNA结合蛋白之间的串扰。阐明基因特异性调节电路可能在将来有助于纠正功能异常的T细胞反应。