Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.,Cell

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Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.
Cell ( IF 45.5 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.cell.2020.01.014
Kenneth Kay ₁ , Jason E Chung ₁ , Marielena Sosa ₁ , Jonathan S Schor ₂ , Mattias P Karlsson ₁ , Margaret C Larkin ₁ , Daniel F Liu ₁ , Loren M Frank ₃

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Cognitive faculties such as imagination, planning, and decision-making entail the ability to represent hypothetical experience. Crucially, animal behavior in natural settings implies that the brain can represent hypothetical future experience not only quickly but also constantly over time, as external events continually unfold. To determine how this is possible, we recorded neural activity in the hippocampus of rats navigating a maze with multiple spatial paths. We found neural activity encoding two possible future scenarios (two upcoming maze paths) in constant alternation at 8 Hz: one scenario per ∼125-ms cycle. Further, we found that the underlying dynamics of cycling (both inter- and intra-cycle dynamics) generalized across qualitatively different representational correlates (location and direction). Notably, cycling occurred across moving behaviors, including during running. These findings identify a general dynamic process capable of quickly and continually representing hypothetical experience, including that of multiple possible futures.

中文翻译：

海马体中可能的未来表示之间的持续亚秒循环。

想象、计划和决策等认知能力需要代表假设经验的能力。至关重要的是，自然环境中的动物行为意味着，随着外部事件的不断展开，大脑不仅可以快速而且随着时间的推移不断地代表假设的未来体验。为了确定这是如何可能的，我们记录了在具有多个空间路径的迷宫中导航的大鼠海马中的神经活动。我们发现神经活动以 8 Hz 的频率持续交替编码两种可能的未来场景（两条即将到来的迷宫路径）：每 ~ 125 毫秒周期一个场景。此外，我们发现循环的基本动态（包括循环间和循环内动态）在质量上不同的代表性相关性（位置和方向）上泛化。尤其，骑自行车发生在运动行为中，包括在跑步期间。这些发现确定了一个能够快速且持续地代表假设经验的一般动态过程，包括多种可能的未来。

更新日期：2020-01-31

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