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Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin.
Cell ( IF 45.5 ) Pub Date : 2020-01-30 , DOI: 10.1016/j.cell.2020.01.006
Wei Zhou 1 , Michelle Spoto 1 , Rachel Hardy 1 , Changhui Guan 1 , Elizabeth Fleming 1 , Peter J Larson 1 , Joseph S Brown 1 , Julia Oh 1
Affiliation  

Metagenomic inferences of bacterial strain diversity and infectious disease transmission studies largely assume a dominant, within-individual haplotype. We hypothesize that within-individual bacterial population diversity is critical for homeostasis of a healthy microbiome and infection risk. We characterized the evolutionary trajectory and functional distribution of Staphylococcus epidermidis-a keystone skin microbe and opportunistic pathogen. Analyzing 1,482 S. epidermidis genomes from 5 healthy individuals, we found that skin S. epidermidis isolates coalesce into multiple founder lineages rather than a single colonizer. Transmission events, natural selection, and pervasive horizontal gene transfer result in population admixture within skin sites and dissemination of antibiotic resistance genes within-individual. We provide experimental evidence for how admixture can modulate virulence and metabolism. Leveraging data on the contextual microbiome, we assess how interspecies interactions can shape genetic diversity and mobile gene elements. Our study provides insights into how within-individual evolution of human skin microbes shapes their functional diversification.

中文翻译:


宿主特异性的进化和传播动力学塑造了人类皮肤中表皮葡萄球菌的功能多样化。



细菌菌株多样性和传染病传播研究的宏基因组推论在很大程度上假设了一种占主导地位的个体内单倍型。我们假设个体内细菌种群多样性对于健康微生物组的稳态和感染风险至关重要。我们表征了表皮葡萄球菌(一种关键的皮肤微生物和机会病原体)的进化轨迹和功能分布。通过分析来自 5 个健康个体的 1,482 个表皮葡萄球菌基因组,我们发现皮肤表皮葡萄球菌分离物合并成多个创始谱系,而不是单个定殖者。传播事件、自然选择和普遍的水平基因转移导致皮肤部位内的群体混合以及抗生素抗性基因在个体内的传播。我们提供了混合物如何调节毒力和代谢的实验证据。利用背景微生物组的数据,我们评估了种间相互作用如何塑造遗传多样性和移动基因元件。我们的研究提供了关于人类皮肤微生物的个体进化如何塑造其功能多样化的见解。
更新日期:2020-01-31
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