Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

中文翻译：

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伤害感受器-肥大细胞感觉簇作为皮肤稳态的调节剂

最近的研究揭示了肥大细胞和皮肤中的伤害感受器之间存在独特的功能联系。在这里，我们建议肥大细胞和伤害感受器在生理学和疾病中形成一个单一的调节单元。在该模型中，MrgprB2/X2 信号传导是肥大细胞与伤害感受器功能性相互作用以形成调节疼痛、炎症和瘙痒的专门神经免疫簇的主要机制。