OBJECTIVE To evaluate intraoperative use of a novel high-density circular grid in detecting after-discharges (AD) on electrocorticography (ECoG) during functional brain mapping (FBM). METHODS FBM during glioma surgery (10/2016 to 5/2019) recorded ADs using a 22-channel circular grid compared to conventional strip electrodes. ADs were analyzed for detection, duration, amplitude, morphology, histology, direction, and clinical signs. RESULTS Thirty-two patients (mean age 54.2 years; r = 30-75) with glioma (WHO grade II-IV; 20 grade IV) had surgery. ADs during FBM were more likely in patients with wild-type as opposed to IDH-1 mutants (p < 0.0001) using more contacts compared with linear strip electrodes (p = 0.0001). More sensors tended to be involved in ADs detected by the circular grid vs strips (6.61 vs 3.43; p = 0.16) at lower stimulus intensity (3.14 mA vs 4.13 mA; p = 0.09). No difference in the number of cortical stimulations before resection was present (38.9 mA vs 47.9 mA; p = 0.26). ADs longer than 10 seconds were 32.5 seconds (circular grid) vs 58.4 (strips) (p = 0.12). CONCLUSIONS High-density circular grids detect ADs in 360 degrees during FBM for glioma resection. Provocation of ADs was more likely in patients with wild-type than IDH-1 mutation. SIGNIFICANCE Circular grids offer high-resolution ECoG during intraoperative FBM for detection of ADs.

中文翻译：

---

使用新型高密度圆形网格在清醒脑肿瘤手术中检测术中功能脑映射过程中的后放电

目的 评估术中使用新型高密度圆形网格在功能性脑映射 (FBM) 期间检测皮层电图 (ECoG) 上的后放电 (AD)。与传统条状电极相比，胶质瘤手术期间的 FBM（10/2016 至 5/2019）使用 22 通道圆形网格记录 AD。分析了 AD 的检测、持续时间、幅度、形态、组织学、方向和临床症状。结果 32 名胶质瘤患者（平均年龄 54.2 岁；r = 30-75）（WHO II-IV 级；20 IV 级）接受了手术。与线性条状电极（p = 0.0001）相比，使用更多接触的野生型患者与 IDH-1 突变体（p < 0.0001）相比，FBM 期间的 ADs 更有可能发生。更多的传感器往往涉及圆形网格与条带检测到的 AD（6.61 对 3.43；p = 0。16) 在较低的刺激强度下 (3.14 mA vs 4.13 mA; p = 0.09)。切除前皮质刺激的数量没有差异（38.9 mA vs 47.9 mA；p = 0.26）。超过 10 秒的广告分别为 32.5 秒（圆形网格）与 58.4 秒（条带）（p = 0.12）。结论 在神经胶质瘤切除的 FBM 过程中，高密度圆形网格可以 360 度检测 AD。与 IDH-1 突变相比，野生型患者更可能诱发 AD。意义圆形网格在术中 FBM 期间提供高分辨率 ECoG，用于检测 AD。结论 在神经胶质瘤切除的 FBM 过程中，高密度圆形网格可以 360 度检测 AD。与 IDH-1 突变相比，野生型患者更可能诱发 AD。意义圆形网格在术中 FBM 期间提供高分辨率 ECoG，用于检测 AD。结论 在神经胶质瘤切除的 FBM 过程中，高密度圆形网格可以 360 度检测 AD。与 IDH-1 突变相比，野生型患者更可能诱发 AD。意义圆形网格在术中 FBM 期间提供高分辨率 ECoG，用于检测 AD。