Increased loneliness has been associated with common mental disorders including psychotic disorders. However, as yet, little information is available on the association between loneliness and the occurrence of psychotic experiences (PEs), especially when adjusted for confounding factors. To address this deficit, the current study examined the relationship between PEs and loneliness in a general population sample in the United States (N = 974). We fitted three regression models to examine the associations between loneliness and PEs, using hierarchical adjustments for sociodemographic factors, adverse childhood experiences, and common mental disorders. Even at the highest level of adjustment, loneliness was significantly associated with increased odds for any PEs (OR = 1.25, 95% CI = 1.13-1.39). The same applied to the association between loneliness and delusional mood (OR = 1.29, 95% CI = 1.15-1.44). For delusion of reference and persecution, delusions of control, and hallucinations, there were no significant associations when adjusted for sociodemographic factors, adverse childhood experiences, and common mental disorders. These results suggest that increased loneliness is associated with PEs, particularly delusional mood. Future studies should employ longitudinal data and biological measures to examine potential causal relationships and underlying mechanisms.

中文翻译：

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一般人群样本中的孤独和精神病经历

孤独感增加与常见的精神障碍有关，包括精神病。然而，迄今为止，关于孤独与精神病经历 (PE) 发生之间关联的信息很少，尤其是在调整了混杂因素后。为了解决这一缺陷，当前的研究在美国的一般人群样本（N = 974）中检查了 PE 与孤独感之间的关系。我们使用对社会人口因素、不良童年经历和常见精神障碍的分层调整，拟合了三个回归模型来检查孤独感与 PE 之间的关联。即使在最高调整水平下，孤独感也与任何 PE 的几率增加显着相关（OR = 1.25，95% CI = 1.13-1.39）。这同样适用于孤独和妄想情绪之间的关联（OR = 1.29，95% CI = 1.15-1.44）。对于参考和迫害妄想、控制妄想和幻觉，在调整社会人口因素、不良童年经历和常见精神障碍后，没有显着关联。这些结果表明孤独感增加与 PE 相关，尤其是妄想情绪。未来的研究应采用纵向数据和生物学措施来检查潜在的因果关系和潜在机制。这些结果表明孤独感增加与 PE 相关，尤其是妄想情绪。未来的研究应采用纵向数据和生物学措施来检查潜在的因果关系和潜在机制。这些结果表明孤独感增加与 PE 相关，尤其是妄想情绪。未来的研究应采用纵向数据和生物学措施来检查潜在的因果关系和潜在机制。