The effector MavC of the bacterial pathogen Legionella pneumophila catalyzes a noncanonical ubiquitination of the host ubiquitin-conjugating E2 enzyme UBE2N by crosslinking a glutamine residue of ubiquitin to UBE2N lysine residues via its transglutaminase activity. A new study by Gan et al (2020) reveals that L. pneumophila reverses this noncanonical ubiquitination via its ubiquitin deamidase effector MvcA to allow precise temporal regulation of host signaling during infection.

中文翻译：

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嗜肺军团菌可平衡泛素转谷氨酰胺。

细菌病原体肺炎军团菌的效应物MavC通过将泛素的谷氨酰胺残基通过其转谷氨酰胺酶活性交联到UBE2N赖氨酸残基来催化宿主泛素缀合E2酶UBE2N的非规范泛素化。Gan等人（2020）的一项新研究表明，嗜肺乳杆菌通过其泛素脱酰胺酶效应器MvcA逆转了这种非规范性泛素化，从而可以在感染过程中精确地调控宿主信号传导的时间。