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Treatment of Netherton Syndrome With Dupilumab.
JAMA Dermatology ( IF 11.5 ) Pub Date : 2020-01-29 , DOI: 10.1001/jamadermatol.2019.4608 Alexa B Steuer 1 , David E Cohen 1
中文翻译：
Dupilumab治疗Netherton综合征。
更新日期：2020-03-12
JAMA Dermatology ( IF 11.5 ) Pub Date : 2020-01-29 , DOI: 10.1001/jamadermatol.2019.4608 Alexa B Steuer 1 , David E Cohen 1
Affiliation
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Netherton syndrome (NS) is an autosomal recessive disorder characterized by congenital ichthyosis, trichorrhexis invaginata, and severe atopy.1 It presents in the neonatal period, and the ichthyosis develops into serpiginous plaques, bordered by a double-edged scale, termed ichthyosis linearis circumflexa. Hair shaft abnormalities present later in life.1,2 We report a case of NS successfully treated with dupilumab, an interleukin (IL) 4 and IL-13 α antagonist.
中文翻译：
Dupilumab治疗Netherton综合征。
Netherton综合征（NS）是一种常染色体隐性遗传疾病，其特征是先天性鱼鳞病，内伤性滴虫和严重特应性。1它出现在新生儿期，鱼鳞病发展成锯齿状斑块，其边界为双刃鳞片，称为线性鱼鳞病。发杆异常出现在以后的生活中。[ 1,2]我们报道了一例成功用白细胞介素（IL）4和IL-13α拮抗剂dupilumab治疗的NS病例。
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