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Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist.
British Journal of Anaesthesia ( IF 9.1 ) Pub Date : 2020-01-29 , DOI: 10.1016/j.bja.2019.11.034
Alexandra L Lewis 1 , Jamie Chaft 1 , Monica Girotra 2 , Gregory W Fischer 1
Affiliation  

Immunotherapy has revolutionised the treatment of oncologic malignancies. Immune checkpoint inhibitors represent a new class of immunotherapy drugs. Although these drugs show promise, they are associated with immune-related adverse reactions. An increasing number of patients who undergo surgery will have had treatment with immune checkpoint inhibitors. In this narrative review article, we discuss their mechanism of action, therapeutic effects, pertinent toxicities, and address specific perioperative considerations for patients treated with immune checkpoint inhibitors.

中文翻译:

免疫检查点抑制剂:对麻醉师注意事项的叙述性回顾。

免疫疗法彻底改变了肿瘤恶性肿瘤的治疗。免疫检查点抑制剂代表了一类新的免疫治疗药物。尽管这些药物显示出希望,但它们与免疫相关的不良反应有关。越来越多接受手术的患者将接受免疫检查点抑制剂治疗。在这篇叙述性综述文章中,我们讨论了它们的作用机制、治疗效果、相关毒性,并解决了接受免疫检查点抑制剂治疗的患者的特定围手术期注意事项。
更新日期:2020-01-30
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