OBJECTIVES To develop short versions of the Frailty Trait Scale (FTS) for use in clinical settings. DESIGN Prospective population-based cohort study. SETTING AND PARTICIPANTS Data from 1634 participants from the Toledo Study for Healthy Aging. METHODS The 12-item Frailty Trait Scale (FTS) reduction was performed based on an area under the curve (AUC) analysis adjusted by age, sex, and comorbidity. Items that maximized prognostic information for adverse events were selected. Each item score was done at the same time as the reduction, identifying the score that maximized the predictive ability for adverse events. For each short version of the FTS, cutoffs that optimized the prognostic information (sensitivity and specificity) were chosen, and their predictive value was later compared with a surrogate gold standard for frailty (the Fried Phenotype). RESULTS Two short forms, the 5-item (FTS5) (range 0-50) and 3-item (FTS3) (range 0-30), were identified, both with AUCs for health adverse events similar to the 12-item FTS. The identified cutoffs were >25 for the FTS5 scale and >15 for the FTS3. The frailty prevalence with these cutoffs was 24% and 20% for the FTS5 and FTS3, respectively, whereas frailty according to Fried Phenotype (FP) reached 8% and prefrailty reached 41%. In general, the FTS5 showed better prognostic performance than the FP, especially with prefrail individuals, in whom the FTS5 form identified 65% of participants with an almost basal risk and 35% with a very high risk for mortality (OR: 4) and frailty (OR: 6.6-8.7), a high risk for hospitalization (OR: 1.9-2.1), and a moderate risk for disability (OR: 1.7) who could be considered frail. The FTS3 form had worse performance than the FTS5, showing 31% of false negatives between frail participants identified by FP with a high risk of adverse events. CONCLUSIONS AND IMPLICATIONS The FTS5 is a short scale that is easy to administer and has a similar performance to the FTS, and it can be used in clinical settings for frailty diagnosis and evolution.

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虚弱特质量表 - 简短形式：临床实践的虚弱工具

目标 开发用于临床环境的虚弱特质量表 (FTS) 的简短版本。设计 基于人群的前瞻性队列研究。设置和参与者 来自托莱多健康老龄化研究的 1634 名参与者的数据。方法 根据年龄、性别和合并症调整的曲线下面积 (AUC) 分析，进行 12 项衰弱特征量表 (FTS) 减少。选择了最大化不良事件预后信息的项目。每个项目评分在减少的同时进行，确定最大化不良事件预测能力的评分。对于每个简短版本的 FTS，都选择了优化预后信息（敏感性和特异性）的临界值，然后将它们的预测值与虚弱的替代金标准（油炸表型）进行比较。结果 确定了两种简短形式，即 5 项 (FTS5)（范围 0-50）和 3 项 (FTS3)（范围 0-30），两者的健康不良事件 AUC 与 12 项 FTS 相似。FTS5 量表的确定临界值 >25，FTS3 的临界值 >15。FTS5 和 FTS3 的这些临界值的虚弱患病率分别为 24% 和 20%，而根据油炸表型 (FP) 的虚弱率达到 8%，虚弱前期达到 41%。总的来说，FTS5 显示出比 FP 更好的预后性能，尤其是对于体弱前个体，其中 FTS5 表确定了 65% 的参与者具有几乎基本的风险，35% 的参与者具有非常高的死亡风险（OR：4）和虚弱（OR：6.6-8.7），住院的高风险（OR：1.9-2.1），以及可能被认为是虚弱的残疾（OR：1.7）的中等风险。FTS3 表的表现比 FTS5 差，显示 FP 确定的具有高不良事件风险的虚弱参与者之间的假阴性率为 31%。结论和意义 FTS5 是一种易于管理且性能与 FTS 相似的短量表，可用于临床环境中的虚弱诊断和演变。