Species of the protozoan Leishmania are causative agents of human leishmaniasis, a disease that results in significant death, disability, and disfigurement around the world. The parasite is transmitted to a mammalian host by a sand fly vector where it develops as an intracellular parasite within macrophages. This process requires the acquisition of nutritional iron and heme from the host as Leishmania lacks the capacity for de novo heme synthesis and does not contain cytosolic iron-storage proteins. Proteins involved in Leishmania iron and heme transport and metabolism have been identified and shown to be crucial for the parasite's growth and replication within the host. Consequently, a detailed understanding of how these parasites harness host pathways for survival may lay the foundation for promising new therapeutic intervention against leishmaniasis.

中文翻译：

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利什曼原虫-宿主界面的铁和血红素代谢。

原生动物利什曼原虫的种类是人类利什曼病的病原体，该疾病在世界范围内导致严重的死亡，残疾和毁容。该寄生虫通过沙蝇载体传播到哺乳动物宿主，在这里它在巨噬细胞内发展为细胞内寄生虫。该过程需要从宿主获得营养性铁和血红素，因为利什曼原虫缺乏从头合成血红素的能力，并且不包含胞质铁存储蛋白。已经鉴定出与利什曼原虫铁，血红素的运输和代谢有关的蛋白质，并显示出该蛋白质对寄生虫在宿主内的生长和复制至关重要。所以，