OBJECTIVE Selenium is an essential trace element. But, selenium may have toxic effects in high doses. There are no proven antidotes or curative treatments for acut selenium toxicity. Treatment involves stopping the exposure and providing supportive care for symptoms. Therefore, it is necessary to find more effective substances in the treatment of selenium toxicity. The aim of this study was to increase the survival rate of animals by supporting the heart with amiodarone and to determine the effect of amiodarone on the pathological, hematological and biochemical parameters in acute selenium intoxication. METHODS 64 Wistar-Albino rats were divided into four groups. Group I was given only distilled water, Group II was given 18 mg/kg dose of amiodarone, Group III was given 18 mg/kg amiodarone and 10 mg/kg sodium selenite and Group IV was given sodium selenite 10 mg/kg (LD50 dose)orally. RESULTS 11 of the 16 animals in Group IV died within the first 48 h of drug administration. However, no deaths were observed in the rats in Group III. No hematological changes were observed. Biochemically, CK, CK-MB and LDH levels of Group IV were higher than the other groups on both the 2nd and 10th days. In Groups II and III, this serum level decreased, and vitamin B12 levels increased. In macroscopic inspections of the organs of Groups III and IV, slight paleness was detected. Histopathologically, degenerative changes in tissue were observed, especially in Group IV. CONCLUSION This study shows that amiodarone application has a reducing effect on selenium toxicity. This was because amiodarone protected the heart by reducing CK and CK-MB levels and increased vitamin B12 levels, which play a role in the synthesis of S-adenosyl methionine that converts selenium into a nontoxic form.

中文翻译：

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抗心律失常药物对急性硒中毒的用途。

目标硒是必需的微量元素。但是，硒在高剂量时可能会产生毒性作用。目前尚无有效的解毒剂或治疗方法可减轻硒的毒性。治疗包括停止接触并为症状提供支持治疗。因此，有必要寻找更有效的硒毒性治疗物质。这项研究的目的是通过用胺碘酮支持心脏来提高动物的存活率，并确定胺碘酮对急性硒中毒的病理，血液学和生化指标的影响。方法将64只Wistar-Albino大鼠分为四组。第一组仅给予蒸馏水，第二组仅给予18 mg / kg胺碘酮，第三组口服给予18 mg / kg胺碘酮和10 mg / kg亚硒酸钠，第四组口服亚硒酸钠10 mg / kg（LD50剂量）。结果IV组16只动物中有11只在给药后48小时内死亡。然而，在第三组的大鼠中未观察到死亡。没有观察到血液学变化。从生化角度看，IV组的CK，CK-MB和LDH水平在第2天和第10天均高于其他组。在第二和第三组中，该血清水平降低，而维生素B12水平升高。在对第III和第IV组器官的宏观检查中，检测到轻微的苍白。在组织病理学上，观察到组织的退行性变化，尤其是在IV组中。结论这项研究表明，胺碘酮对硒的毒性具有降低作用。