Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type,Movement Disorders

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Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type
Movement Disorders ( IF 8.6 ) Pub Date : 2020-01-29 , DOI: 10.1002/mds.27987
Jennifer Faber _{1,

2} , Ilaria Giordano _{1,

2} , Xueyan Jiang ₁ , Christine Kindler _{1,

2} , Annika Spottke _{1,

2} , Julio Acosta-Cabronero ₃ , Peter J Nestor _{4,

5} , Judith Machts _{6,

7} , Emrah Düzel _{6,

7} , Stefan Vielhaber _{6,

7} , Oliver Speck _{6,

8,

9} , Ales Dudesek ₁₀ , Christoph Kamm ₁₀ , Lukas Scheef _{1,

11} , Thomas Klockgether _{1,

2}

Affiliation

Clinical Research, German Center for Neurodegenerative Diseases, Bonn, Germany.
Department of Neurology, University Hospital Bonn, Germany.
Tenoke Ltd., Cambridge, United Kingdom.
Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Neuroscience and Cognitive Health Program, Mater Hospital, South Brisbane, Australia.
German Center for Neurodegenerative Diseases, Magdeburg, Germany.
Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany.
Department of Biomedical Magnetic Resonance, Faculty for Natural Sciences, Otto-von-Guericke University, Magdeburg, Germany.
Center for Behavioral Brain Sciences, Magdeburg, Germany.
Department of Neurology, University of Rostock, Rostock, Germany.
Department of Radiology, University of Bonn, Bonn, Germany.

Sporadic degenerative ataxia patients fall into 2 major groups: multiple system atrophy with predominant cerebellar ataxia (MSA‐C) and sporadic adult‐onset ataxia (SAOA). Both groups have cerebellar volume loss, but little is known about the differential involvement of gray and white matter in MSA‐C when compared with SAOA.

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