Type 1 diabetes-early life origins and changing epidemiology.,The Lancet Diabetes & Endocrinology

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Type 1 diabetes-early life origins and changing epidemiology.
The Lancet Diabetes & Endocrinology ( IF 44.0 ) Pub Date : 2020-01-27 , DOI: 10.1016/s2213-8587(19)30412-7
Jill M Norris ₁ , Randi K Johnson ₂ , Lars C Stene ₃

Affiliation

Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has increased 3-4% over the past three decades, supporting the role of environmental factors. Although several factors have been associated with type 1 diabetes, none of the associations are of a magnitude that could explain the rapid increase in incidence alone. Moreover, evidence of changing prevalence of these exposures over time is insufficient. Multiple factors could simultaneously explain the changing type 1 diabetes incidence, or the magnitude of observed associations could have been underestimated because of exposure measurement error, or the mismodelling of complex exposure-time-response relationships. The identification of environmental factors influencing the risk of type 1 diabetes and increased understanding of the cause at the individual level, regardless of the ability to explain the changing incidence at the population level, is important because of the implications for prevention.

中文翻译：

1型糖尿病-早期生命起源和流行病学变化。

1型糖尿病是一种慢性的，免疫介导的疾病，其特征是胰岛素产生细胞的破坏。标准化的注册表数据显示，过去三十年来1型糖尿病的发病率增加了3-4％，这支持了环境因素的作用。尽管与1型糖尿病相关的因素有很多，但没有一个因素能够单独解释发病率的快速上升。此外，这些暴露的流行率随时间变化的证据不足。多种因素可以同时解释1型糖尿病发病率的变化，或者由于暴露测量误差或复杂的暴露-时间-反应关系的建模错误，可能低估了观察到的关联的程度。

更新日期：2020-02-19

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