The development of potent cholesterol-reducing medications in the last decade of the twentieth century has altered the approach to prevention and treatment of cardiovascular disease (CVD). Initial experience with statins, and more recently with the addition of PCSK9 inhibitors, has proven that human CVD, like that in animal models, can be halted and regressed. Available clinical data show that the lower the achieved level of low-density lipoprotein cholesterol, the greater the regression of disease. Investigative studies are now aimed to understand those factors that both accelerate and impede this healing process. Some of these are likely to be modifiable, and the future of atherosclerotic CVD treatment is likely to be early screening, use of measures to repair atherosclerotic arteries, and prevention of most CVD events.

中文翻译：

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动脉粥样硬化：掉头。

在二十世纪最后十年中，有效的降低胆固醇药物的开发改变了预防和治疗心血管疾病（CVD）的方法。他汀类药物的最初经验以及最近添加PCSK9抑制剂的经验都证明，与动物模型一样，人类CVD可以停止并消退。现有的临床数据表明，低密度脂蛋白胆固醇达到的水平越低，疾病的消退就越大。现在的调查研究旨在了解那些既加速又阻碍这一愈合过程的因素。其中一些可能是可修改的，而动脉粥样硬化CVD治疗的未来可能是早期筛查，使用修复动脉粥样硬化动脉的措施以及预防大多数CVD事件。