OBJECTIVES This study aimed to evaluate the associations between ambient air pollutants, obesity, and kidney function. SUBJECTS/METHODS We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO), in each subject's residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function. RESULTS High PM10, NO2, SO2, and CO concentrations were significantly associated with decreased kidney function (β = -2.39 and standard error = 0.32, -1.00 and 0.31, -1.23 and 0.28, and -1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM10, 1.42 vs 1.21 for SO2, and 1.27 vs 1.11 for CO). CONCLUSIONS Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. This may indicate a high susceptibility to air pollutants in obese people.

中文翻译：

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腹部肥胖对空气污染与肾功能之间关系的影响。

目的 本研究旨在评估环境空气污染物、肥胖症和肾功能之间的关联。对象/方法 我们招募了 3345 名在首尔国立大学医院接受过健康检查的人。我们记录了每个受试者居住区的环境空气污染物年平均浓度，包括空气动力学直径≤10μm的颗粒物（PM10）、二氧化氮（NO2）、二氧化硫（SO2）和一氧化碳（CO） . 通过量化计算机断层扫描 (CT) 测量各种肥胖特征，如体重指数、腰围、内脏和皮下脂肪组织面积，并根据估计的肾小球滤过率评估肾功能，作为肾功能的指标。结果 PM10、NO2、SO2、和 CO 浓度与肾功能下降显着相关（β = -2.39 和标准误差 = 0.32、-1.00 和 0.31、-1.23 和 0.28，以及 -1.32 和 0.29），以及慢性肾病（CKD）的患病率）。空气污染物浓度与肾功能下降（包括 CKD）之间的相关性在高腹部肥胖者中更强，如 CT 测量所定义。例如，空气污染物浓度增加与 CKD 患病率之间的相关性在内脏肥胖程度较高的组中比在内脏肥胖程度较低的组中更强（aORs = 1.29 vs 1.16 PM10，1.42 vs 1.21 SO2 和 1.27与 CO 的 1.11 相比）。结论 长期暴露于较高浓度的空气污染物与肾功能和 CKD 患病率不利相关，尤其是在腹部肥胖的人群中。这可能表明肥胖人群对空气污染物的敏感性很高。