Thermoresponsive polymers in water, for example, poly(N‐isopropylacrylamide) (PNIPAM) are investigated extensively, due to a wide range of biomedical applications. However, the attempts to control thermoresponsiveness are still rare in less or nonpolar media. Herein, the three thermoresponsive homopolymers tethering an N‐butylurea group in the side chain with a different polymer backbone are reported. They exhibit lower critical solution temperature (LCST)‐type and upper critical solution temperature (UCST)‐type thermoresponsiveness depending on association of the urea group in the polymer chain and hydrogen bonding small molecules (effectors) in ternary systems (polymer/effector/organic solvent). The difference of polymer backbone appears as their change of solvophobicity in organic solvents. Poly(methacrylate) backbone needs more amount of the effector in nonpolar organic solvents, and poly(vinyl ether) backbone needs more amount in polar organic solvents. However, the influence of polymer backbone is too little to change the phase transition behavior, and the thermoresponsiveness is dominated by association and dissociation of hydrogen bondings between polymers and effectors. The supramolecular design of the thermoresponsive polymers is strong and extensible for the design of their phase transitions.

中文翻译：

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超分子设计的不同聚合物骨架的热响应聚合物

由于生物医学的广泛应用，对水中的热响应性聚合物，例如聚（N-异丙基丙烯酰胺）（PNIPAM）进行了广泛的研究。但是，在较少或非极性介质中，控制热响应性的尝试仍然很少。在此，三种热敏均聚物将N据报道，侧链中的-丁基脲基具有不同的聚合物主链。它们显示出较低的临界溶液温度（LCST）型和较高的临界溶液温度（UCST）型热响应性，具体取决于聚合物链中脲基与三元体系（聚合物/效应器/有机物）中氢键结合的小分子（效应物）的相关性溶剂）。聚合物主链的差异表现为它们在有机溶剂中的疏溶剂性变化。聚（甲基丙烯酸酯）主链在非极性有机溶剂中需要更多的效应子，而聚（乙烯基醚）主链在极性有机溶剂中需要更多的效应子。但是，聚合物主链的影响很小，无法改变相变行为，聚合物和效应器之间氢键的缔合和解离决定了热响应性。热响应性聚合物的超分子设计对于其相变设计而言是坚固且可扩展的。