An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach,Macromolecular Chemistry and Physics

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An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2020-01-29 , DOI: 10.1002/macp.201900466
Rafael Dera ₁ , Hanne Diliën ₂ , Peter Adriaensens ₁ , Wanda Guedens ₁ , Thomas J. Cleij ₂

Affiliation

Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the foreign body response. In this work, phosphodiester‐crosslinked hydrogels are produced by a simple free‐radical polymerization of a phosphotriester crosslinker. In a second step, this material is transformed to the phosphodiester, by heating it up to 60 °C in phosphate‐buffered saline. Compared to earlier methods, there is no need for acids, bases, or oxidizing agents to achieve this final conversion to the phosphodiester. This method thus reduces the risk to damage or degrade any sensitive biomolecules that might be of interest to tissue engineers, such as various growth factors or other proteins. The phosphotriester crosslinker is readily synthesized out of common laboratory chemicals in multigram quantities with good yield and easy workup and purification.

中文翻译：

通过前体方法向磷酸二酯水凝胶的高效热消除途径

磷酸二酯水凝胶具有多种引人入胜的特性。它们不仅显示出出色的血液相容性和细胞相容性，而且还显示出显着的抗蛋白质吸附能力，从而限制了异物应答。在这项工作中，磷酸二酯交联的水凝胶是通过磷酸三酯交联剂的简单自由基聚合反应制得的。第二步，通过在磷酸盐缓冲液中将其加热至60°C，将其转化为磷酸二酯。与早期方法相比，不需要酸，碱或氧化剂来实现最终转化为磷酸二酯。因此，该方法降低了损害或降解组织工程师可能感兴趣的任何敏感生物分子的风险，例如各种生长因子或其他蛋白质。

更新日期：2020-01-29

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