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The Emerging Role of Adhesion GPCRs in Cancer
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-01-28 , DOI: 10.1021/acsptsci.9b00093 Abanoub A. Gad 1, 2 , Nariman Balenga 2, 3
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-01-28 , DOI: 10.1021/acsptsci.9b00093 Abanoub A. Gad 1, 2 , Nariman Balenga 2, 3
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Aberrant expression, function, and mutation of G protein-coupled receptors (GPCRs) and their signaling partners, G proteins, have been well documented in many forms of cancer. These cell surface receptors and their endogenous ligands are implicated in all aspects of cancer including proliferation, angiogenesis, invasion, and metastasis. Adhesion GPCRs (aGPCRs) form the second largest family of GPCRs, most of which are orphan receptors with unknown physiological functions. This is mainly due to our limited insight into their structure, natural ligands, signaling pathways, and tissue expression profiles. Nevertheless, recent studies show that aGPCRs play important roles in cell adhesion to the extracellular matrix and cell–cell communication, processes that are dysregulated in cancer. Emerging evidence suggests that aGPCRs are implicated in migration, proliferation, and survival of tumor cells. We here review the role of aGPCRs in the five most common types of cancer (lung, breast, colorectal, prostate, and gastric) and emphasize the importance of further translational studies in this field.
中文翻译：
粘附GPCR在癌症中的新兴作用。
G蛋白偶联受体（GPCR）及其信号伴侣G蛋白的异常表达，功能和突变已在许多形式的癌症中得到了充分证明。这些细胞表面受体及其内源性配体与癌症的各个方面有关，包括增殖，血管生成，侵袭和转移。粘附GPCR（aGPCR）构成了GPCR的第二大家族，其中大多数是具有未知生理功能的孤儿受体。这主要是由于我们对它们的结构，天然配体，信号传导途径和组织表达谱的了解有限。然而，最近的研究表明，aGPCR在细胞粘附至细胞外基质和细胞间通讯中起着重要作用，而这些过程在癌症中失调。新兴证据表明，aGPCR与肿瘤细胞的迁移，增殖和存活有关。我们在这里回顾了aGPCR在五种最常见的癌症类型（肺癌，乳腺癌，结直肠癌，前列腺癌和胃癌）中的作用，并强调了在该领域进行进一步转化研究的重要性。
更新日期：2020-01-29
中文翻译：
粘附GPCR在癌症中的新兴作用。
G蛋白偶联受体（GPCR）及其信号伴侣G蛋白的异常表达，功能和突变已在许多形式的癌症中得到了充分证明。这些细胞表面受体及其内源性配体与癌症的各个方面有关，包括增殖，血管生成，侵袭和转移。粘附GPCR（aGPCR）构成了GPCR的第二大家族，其中大多数是具有未知生理功能的孤儿受体。这主要是由于我们对它们的结构，天然配体，信号传导途径和组织表达谱的了解有限。然而，最近的研究表明，aGPCR在细胞粘附至细胞外基质和细胞间通讯中起着重要作用，而这些过程在癌症中失调。新兴证据表明，aGPCR与肿瘤细胞的迁移，增殖和存活有关。我们在这里回顾了aGPCR在五种最常见的癌症类型（肺癌，乳腺癌，结直肠癌，前列腺癌和胃癌）中的作用，并强调了在该领域进行进一步转化研究的重要性。
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