The NLRP6 inflammasome in health and disease.,Mucosal Immunology

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The NLRP6 inflammasome in health and disease.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2020-01-27 , DOI: 10.1038/s41385-020-0256-z
Laxman Ghimire ₁ , Sagar Paudel ₁ , Liliang Jin ₁ , Samithamby Jeyaseelan _{1,

2}

Affiliation

NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols the cytosolic compartment of cells to detect pathogen- and damage-associated molecular patterns. Because Nlrp6 is a recently discovered inflammasome, details of its signaling mechanism, structural assembly, and roles in host defense have yet to be determined. To date, Nlrp6 has been proposed to perform a multitude of functions ranging from control of microbiota, maintenance of epithelial integrity, and regulation of metabolic diseases to modulation of host defense during microbial infections, cancer protection, and regulation of neuroinflammation. While recent studies have questioned some of the proposed functions of Nlrp6, Nlrp6 has been shown to form an inflammasome complex and cleaves interleukin-1β (IL-1β) and IL-18 during microbial infection, indicating that it is a bonafide inflammasome. In this review, we summarize the recent advancements in knowledge of the signaling mechanisms and structure of the Nlrp6 inflammasome and discuss the relevance of NLRP6 to human disease.

中文翻译：

NLRP6 炎性体在健康和疾病中的作用。

含有 NACHT、LRR（富含亮氨酸重复序列）和 PYD（pyrin 结构域）结构域的 6 (Nlrp6) 是 NLR（核苷酸寡聚结构域样受体）家族的成员，可巡逻细胞的胞质区室以检测病原体。和损伤相关的分子模式。由于 Nlrp6 是最近发现的炎症小体，其信号机制、结构组装以及在宿主防御中的作用的细节尚未确定。迄今为止，Nlrp6 已被认为具有多种功能，从控制微生物群、维持上皮完整性、调节代谢疾病到调节微生物感染期间的宿主防御、癌症保护和调节神经炎症。虽然最近的研究对 Nlrp6 的一些功能提出了质疑，但 Nlrp6 已被证明可形成炎症小体复合物，并在微生物感染过程中裂解白细胞介素 1β (IL-1β) 和 IL-18，这表明它是一种真正的炎症小体。在这篇综述中，我们总结了 Nlrp6 炎症小体信号传导机制和结构的最新进展，并讨论了 NLRP6 与人类疾病的相关性。

更新日期：2020-01-27

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