BACKGROUND Healthy aging is particularly important in women, as their life-span is generally longer than men's, leaving women at higher risk for age-related diseases. Understanding determinants of women's healthy aging is therefore a major public health interest. Clinical utility of previous research is limited, through its focus on either single psychosocial or biological predictors. The present study investigated psychobiological predictors of women's healthy aging, for the first time including positive psychological traits and biomarkers of healthy aging. METHODS Totally, 121 generally healthy women aged 40 to 75 were investigated cross-sectionally. Healthy aging was operationalized via self-rated health (SRH). To gain a nuanced view of the particularities at the upper end of the illness-wellness continuum, women with excellent SRH and those with good SRH were analyzed as distinct groups. Socioeconomic and sociodemographic variables, health behavior, resilience, optimism, and self-worth as well as menopausal symptoms, and levels of steroid hormones and gonadotropins were considered as predictors of SRH. Binary logistic regression analyses using the forward conditional method were performed with the two health status groups as dependent variable. RESULTS Women with a lower body mass index (BMI; OR = .59, 95% CI = .33-1.03), higher intensive physical activity (OR = 2.27, 95% CI = 1.06-4.86), and higher resilience (OR = 2.37, 95% CI = 1.34-4.18) were more likely to rate their health as excellent compared to good. No clinically significant differences could be found regarding endocrine levels. CONCLUSION Psychobiological indicators (lower BMI, intensive physical activity, higher resilience) discriminated SRH at the top level of the health spectrum. In healthy women, the predictive value of endocrine markers seems to be secondary. Interventions targeting these indicators could promote women's healthy aging.

中文翻译：

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主观经历过的健康状况的心理生物学指标-妇女40岁以上健康老龄化研究的发现。

背景技术健康的衰老在女性中尤其重要，因为它们的寿命通常比男性更长，从而使女性处于与年龄有关的疾病的较高风险中。因此，了解妇女健康衰老的决定因素是公共卫生的主要兴趣。通过集中于单一的社会心理或生物学预测因素，先前研究的临床实用性受到限制。本研究首次调查了女性健康衰老的心理生物学指标，其中包括积极的心理特征和健康衰老的生物标志物。方法总共对121名40至75岁的健康女性进行了横断面调查。通过自评健康（SRH）实现健康老龄化。为了细致了解疾病-健康连续体高端的特殊性，SRH优良的女性和SRH优良的女性被分为不同的组。社会经济和社会人口统计学变量，健康行为，适应力，乐观情绪和自我价值以及更年期症状以及类固醇激素和促性腺激素的水平被认为是SRH的预测指标。使用前向条件方法进行二元逻辑回归分析，将两个健康状况组作为因变量。结果妇女的体重指数较低（BMI; OR = .59，95％CI = 0.33-1.03），强度较高的体育锻炼（OR = 2.27，95％CI = 1.06-4.86），弹性较高（OR = 2.37，95％CI = 1.34-4.18）更有可能将其健康状况评为“好”。关于内分泌水平，没有发现临床上的显着差异。结论心理生物学指标（较低的BMI，剧烈的体育活动，更高的适应力）在健康谱图中将SRH区分为SRH。在健康女性中，内分泌标志物的预测价值似乎是次要的。针对这些指标的干预措施可以促进妇女的健康衰老。