The present article reports on the synthesis of mesoporous alumina and its modification through $$\upbeta $$ β -cyclodextrin (BCD) incorporation for loading and release studies of amoxicillin. The drug loading in the mesoporous matrices was found to be activated upon providing molecular assistance by amino acids, L-methionine, L-proline and L-phenylalanine. The effect of molecular assistance has been attributed to intermolecular interactions between the drug and the individual amino acids which have been further confirmed by different spectroscopic studies. The drug-loaded material with BCD modification was found to exhibit a sustained release mechanism in physiological pH and is suggested as a proposed material for hip joint prosthesis.

中文翻译：

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原始和改性介孔氧化铝：基于分子辅助的载药和缓释活性

本文报道了介孔氧化铝的合成及其通过 $$\upbeta $$ β-环糊精 (BCD) 掺入进行改性，用于阿莫西林的加载和释放研究。发现介孔基质中的载药量在氨基酸、L-甲硫氨酸、L-脯氨酸和 L-苯丙氨酸提供分子辅助后被激活。分子辅助的作用归因于药物与单个氨基酸之间的分子间相互作用，这已被不同的光谱研究进一步证实。发现具有 BCD 修饰的载药材料在生理 pH 值下表现出持续释放机制，并建议作为髋关节假体的材料。