Sensing bacterial infections and monitoring drug resistance are very important for the selection of treatment options. However, the common methods of sensing resistance are limited by time-consuming, the requirement for professional personnel, and expensive instruments. Moreover, the abuse of antibiotics causes the accelerated process of bacterial resistance. Herein, we construct a portable paper-based band-aid (PBA) which implements a selective antibacterial strategy after sensing of drug resistance. The colors of PBA indicate bacterial infection (yellow) and drug resistance (red), just like a bacterial resistance colorimetric card. On the basis of color, antibiotic-based chemotherapy and Zr-MOF PCN-224-based photodynamic therapy (PDT) are used on site to treat sensitive and resistant strains, respectively. Eventually, it takes 4 h to sense, and the limit of detection is 104 CFU/mL for drug-resistant E. coli. Compared with traditional PDT-based antibacterial strategies, our design can alleviate off-target side effects, maximize therapeutic efficacy, and track the drug resistance in real time with the naked eye. This work develops a new way for the rational use of antibiotics. Given the low cost and easy operation of this point-of-care device, it can be developed for practical applications.

中文翻译：

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用于现场护理和细菌感染的比色创可贴。

感觉细菌感染和监测耐药性对于选择治疗方案非常重要。但是，普通的电阻检测方法受到时间的限制，专业人员的需求以及昂贵的仪器的限制。而且，抗生素的滥用导致细菌抗性的加速过程。本文中，我们构建了一种便携式纸基创可贴（PBA），在感测到耐药性后即可实施选择性抗菌策略。PBA的颜色表示细菌感染（黄色）和耐药性（红色），就像细菌耐药性比色卡一样。基于颜色，在现场使用基于抗生素的化学疗法和基于Zr-MOF PCN-224的光动力疗法（PDT）分别治疗敏感和耐药菌株。最终，要花4个小时才能感觉到，耐药大肠杆菌的检出限为104 CFU / mL。与传统的基于PDT的抗菌策略相比，我们的设计可以减轻脱靶副作用，最大化治疗效果并用肉眼实时跟踪耐药性。这项工作为合理使用抗生素开辟了一条新途径。鉴于此即时护理设备的成本低廉且易于操作，因此可以针对实际应用进行开发。