当前位置: X-MOL 学术Bioconjugate Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Enzyme-Instructed Self-Assembly for Cancer Therapy and Imaging.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-02-07 , DOI: 10.1021/acs.bioconjchem.0c00025
Beom Jin Kim 1 , Bing Xu 1
Affiliation  

Enzymatic reactions and self-assembly are two fundamental attributes of cells. It is not surprising that one can use enzyme-instructed self-assembly (EISA)-the integration of enzymatic transformation and molecular self-assembly-to modulate the emergent properties of supramolecular assemblies for controlling cell behaviors. The exploration of EISA for developing cancer therapy and imaging has made considerable progress over the last five years. In this Topical Review, we discuss these exciting results and the future promise of EISA. After describing several key studies to illustrate the progress of EISA in developing cancer therapy, we discuss the use of EISA for molecular imaging. Then, we give the outlook of EISA for developing supramolecular anticancer medicine that inhibits multiple hallmark capabilities of cancer.

中文翻译:

酶指导的自组装,用于癌症治疗和成像。

酶促反应和自组装是细胞的两个基本属性。毫不奇怪,可以使用酶指导的自组装(EISA)-酶促转化和分子自组装的结合来调节超分子组装的新兴特性来控制细胞行为。在过去的五年中,对开发用于癌症治疗和影像学的EISA的探索取得了长足的进步。在本专题回顾中,我们讨论了这些令人兴奋的结果以及EISA的未来前景。在描述了一些关键研究以说明EISA在开发癌症治疗方面的进展之后,我们讨论了EISA在分子成像中的用途。然后,我们给出了EISA的前景,即开发出抑制多种癌症特征的超分子抗癌药物。
更新日期:2020-02-07
down
wechat
bug