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Correction to "Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms".
Journal of Medicinal Chemistry ( IF 7.3 ) Pub Date : 2020-01-27 , DOI: 10.1021/acs.jmedchem.0c00025
Tao Yang , Mengshi Hu , Wenyan Qi , Zhuang Yang , Minghai Tang , Jun He , Yong Chen , Peng Bai , Xue Yuan , Chufeng Zhang , Kongjun Liu , Yulin Lu , Mingli Xiang , Lijuan Chen

In Figure 2A, the molecule structure in the cavity of the JAK2 protein was wrong. In Figure 6A, the last two pictures were the same. The correct figures are presented as follows. Figure 2. (A) Docking result of the designed compound (molecule B) in the JAK2 protein (PDB code: 2XA4); (B) docking result of the designed compound (molecule B) in the FLT3 protein (PDB code: 4RT7). Figure 6. (A) Cell cycle effects of 18e on MV4–11 cells. Cells were treated with increasing concentrations of 18e for 24 h, harvested, fixed, and stained with propidium iodide prior to flow cytometric analysis. (B) Effects of 18e on the induction of apoptosis. This article has not yet been cited by other publications. Figure 2. (A) Docking result of the designed compound (molecule B) in the JAK2 protein (PDB code: 2XA4); (B) docking result of the designed compound (molecule B) in the FLT3 protein (PDB code: 4RT7). Figure 6. (A) Cell cycle effects of 18e on MV4–11 cells. Cells were treated with increasing concentrations of 18e for 24 h, harvested, fixed, and stained with propidium iodide prior to flow cytometric analysis. (B) Effects of 18e on the induction of apoptosis.

中文翻译:

更正为“发现有效和口服有效的双重Janus激酶2 / FLT3抑制剂,用于治疗急性骨髓性白血病和骨髓增生性肿瘤”。

在图2A中,JAK2蛋白腔中的分子结构是错误的。在图6A中,最后两张图片是相同的。正确的数字如下所示。图2.(A)设计的化合物(分子B)与JAK2蛋白(PDB代码:2XA4)的对接结果;(B)设计的化合物(分子B)与FLT3蛋白(PDB代码:4RT7)的对接结果。图6.(A)18e对MV4-11细胞的细胞周期影响。在流式细胞术分析之前,将细胞以增加的18e浓度处理24小时,收获,固定并用碘化丙啶染色。(B)18e的影响对细胞凋亡的诱导。本文尚未被其他出版物引用。图2.(A)设计的化合物(分子B)与JAK2蛋白(PDB代码:2XA4)的对接结果;(B)设计的化合物(分子B)与FLT3蛋白(PDB代码:4RT7)的对接结果。图6.(A)18e对MV4-11细胞的细胞周期影响。在流式细胞术分析之前,以浓度增加的18e处理细胞24小时,收获,固定并用碘化丙啶染色。(B)18e对诱导细胞凋亡的作用。
更新日期:2020-01-29
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