Monoclonal antibodies recognize epitopes so specifically that altering a single residue can disrupt binding. In this issue of Science Signaling, Schüchner et al and Frohner et al report that flanking amino acids and an underappreciated posttranslational modification perturb epitope affinity for two groups of widely used monoclonal antibodies.

中文翻译：

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脆弱的抗原决定簇-抗体的猜测与您的猜测一样好。

单克隆抗体可特异性识别表位，因此改变单个残基可破坏结合。在本期《科学信号》中，Schüchner等人和Frohner等人报道了侧翼氨基酸和翻译后修饰不足的现象扰乱了两组广泛使用的单克隆抗体的表位亲和力。