Abstract The 48 most widely sold retail EPA/DHA omega-3 fatty acid dietary supplements on the U.S. market were tested for EPA + DHA label claim compliance and for oxidative quality. Each product was tested by at least three laboratories using validated methods. Most EPA/DHA products have a nutrient content consistent with the label declaration and contain levels of oxidation in accordance with industry and pharmacopeial quality requirements. It is challenging to evaluate the compliance for products sold in the U.S. given the lack of government regulations on oxidative quality specific to dietary supplements and content labeling requirements that are currently not clear. 48 % of the products contained less than the EPA + DHA amount declared on the label, although they are still within the current legal range. Adequate product storage conditions are suggested based on absence of correlation between the chemical markers and product expiration. Some limitations exist in the use of current methods to evaluate oxidative stability. Marked inter-laboratory variability was found when the same product is analyzed. Room for improvement in quality of EPA/DHA finished products in the U.S. is suggested since nearly half of 17 tested products for which all quality parameters could be tested did not meet at least one.

中文翻译：

---

美国 EPA/DHA omega-3 零售产品的成分标签声明合规性和氧化质量

摘要 对美国市场上 48 种最广泛销售的零售 EPA/DHA omega-3 脂肪酸膳食补充剂进行了 EPA + DHA 标签声明合规性和氧化质量测试。每个产品至少由三个实验室使用经过验证的方法进行测试。大多数 EPA/DHA 产品的营养成分与标签声明一致，并且含有符合行业和药典质量要求的氧化水平。由于缺乏针对膳食补充剂的氧化质量的政府法规和目前尚不明确的内容标签要求，因此评估在美国销售的产品的合规性具有挑战性。48% 的产品含有低于标签上声明的 EPA + DHA 量，尽管它们仍在当前的法律范围内。根据化学标志物与产品有效期之间不存在相关性，建议采用适当的产品储存条件。使用当前的方法来评估氧化稳定性存在一些限制。当分析相同的产品时，发现了明显的实验室间差异。美国 EPA/DHA 成品质量存在改进空间，因为 17 种可测试所有质量参数的测试产品中，近一半不符合至少一项。