Evidence indicates that higher serum 25-hydroxy vitamin D levels may be associated with decreased prevalence of urgency urinary incontinence (UI), but the impact of vitamin D consumption on development of urgency and mixed UI is unclear. The objective was to assess whether greater vitamin D intake was associated with decreased risk of incident urgency and mixed UI over 10 years using 2 large prospective cohorts of middle-aged and older women. We analyzed 38,101 women from the Nurses' Health Study I (NHS I) and 35,190 women from NHS II who were free of UI at baseline. We followed incident UI, defined as new UI occurring at least monthly, separately by subtype (urgency, mixed, stress UI), from 2002-2012. We categorized vitamin D intake from supplements and diet. We estimated relative risk for developing UI according to vitamin D intake using Cox-proportional hazard models with adjustment for covariates. Median vitamin D intake was 580IU in the older women in NHS I (age range 56-71 at baseline) and 487IU in middle-aged women in NHS II (age range 40-57). Among women taking ≥1000IU of vitamin D, median intake in the older women was 1252IU and 1202IU in the middle-aged women. Among the older women, we found no relation of vitamin D intake to risk of developing UI, across all UI subtypes. In multivariable-adjusted analysis for middle-aged women, the relative risk of developing mixed UI among women taking >1000IU was 0.79 (0.63, 0.99) and for urgency UI was 0.88 (0.71, 1.07), versus <200IU. Risks of developing stress UI were not related to vitamin D intake categories. Overall, we did not find a relationship between vitamin D intake and UI incidence in middle-aged and older women; however, the reported intake was moderate.

中文翻译：

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维生素 D 摄入量和女性 10 年急迫性尿失禁的风险。

有证据表明，血清 25-羟基维生素 D 水平较高可能与急迫性尿失禁 (UI) 患病率降低有关，但维生素 D 摄入量对尿急和混合性尿失禁的影响尚不清楚。目的是使用 2 个大型中年和老年女性前瞻性队列来评估 10 年来更多的维生素 D 摄入量是否与降低事件紧迫性和混合 UI 的风险相关。我们分析了护士健康研究 I (NHS I) 中的 38,101 名女性和 NHS II 中的 35,190 名基线时没有 UI 的女性。我们跟踪了 2002 年至 2012 年期间发生的 UI 事件，定义为至少每月发生一次的新 UI，按子类型（紧急、混合、压力 UI）分别进行分析。我们对补充剂和饮食中的维生素 D 摄入量进行了分类。我们使用 Cox 比例风险模型并调整协变量，根据维生素 D 摄入量估计了发生 UI 的相对风险。NHS I 中老年女性（基线年龄范围 56-71 岁）的维生素 D 摄入量中位数为 580IU，NHS II 中中年女性（年龄范围 40-57 岁）维生素 D 摄入量中位数为 487IU。在服用≥1000IU维生素D的女性中，老年女性的中位摄入量为1252IU，中年女性为1202IU。在老年女性中，我们发现维生素 D 摄入量与所有 UI 亚型中发生 UI 的风险没有关系。在针对中年女性的多变量调整分析中，服用>1000IU的女性发生混合UI的相对风险为0.79（0.63，0.99），而紧急UI的相对风险为0.88（0.71，1.07），而服用<200IU的女性则为0.88（0.71，1.07）。发生压力性 UI 的风险与维生素 D 摄入量类别无关。总体而言，我们没有发现中老年女性维生素 D 摄入量与 UI 发病率之间存在关系；然而，报告的摄入量适中。