Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top of injury repair, cell plasticity is a constant physiological process in adult organisms and tissues, in response to homeostatic challenges. In this review we discuss two examples of plasticity for the maintenance of homeostasis in the renal system-namely the renin-producing juxtaglomerular cells (JG cells) and cortical collecting duct (CCD) cells. JG cells show plasticity through recruitment mechanisms, answering the demand for an increase in renin production. In the CCD, cells appear to have the ability to transdifferentiate between principal and intercalated cells to help maintain the highly regulated solute transport levels of that segment. These two cases highlight the complexity of plasticity processes and the role they can play in the kidney.

中文翻译：

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细胞可塑性：肾脏体内稳态的一种机制。

细胞可塑性是一门热门话题，涉及从发育生物学到再生医学的广泛领域。甚至术语也成为争论的话题，其潜在机制仍在调查中。除损伤修复外，细胞可塑性是成年生物和组织中不断发生的生理过程，以应对体内平衡挑战。在这篇综述中，我们讨论了用于维持肾脏系统稳态的可塑性的两个例子，即产生肾素的近肾小球细胞（JG细胞）和皮质收集管（CCD）细胞。JG细胞通过募集机制表现出可塑性，满足了肾素产量增加的需求。在CCD中 细胞似乎具有在主细胞和插层细胞之间转分化的能力，以帮助维持该区段的高度调节的溶质转运水平。这两个案例突出了可塑性过程的复杂性及其在肾脏中的作用。