A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.

中文翻译：

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线粒体根加速衰老和脆弱。

在一大批成年人中进行了一项发现代谢组学研究，以鉴定脆弱的循环生物标志物。研究发现，与非体弱的参与者相比，体弱的肉碱和维生素E途径失调。这些发现表明，线粒体代谢失调可能是与年龄相关的衰弱的潜在根源。