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A mitochondrial root to accelerated ageing and frailty.
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41574-020-0319-y Luigi Ferrucci 1 , Marta Zampino 1
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41574-020-0319-y Luigi Ferrucci 1 , Marta Zampino 1
Affiliation
A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
中文翻译:
线粒体根加速衰老和脆弱。
在一大批成年人中进行了一项发现代谢组学研究,以鉴定脆弱的循环生物标志物。研究发现,与非体弱的参与者相比,体弱的肉碱和维生素E途径失调。这些发现表明,线粒体代谢失调可能是与年龄相关的衰弱的潜在根源。
更新日期:2020-01-28
中文翻译:
线粒体根加速衰老和脆弱。
在一大批成年人中进行了一项发现代谢组学研究,以鉴定脆弱的循环生物标志物。研究发现,与非体弱的参与者相比,体弱的肉碱和维生素E途径失调。这些发现表明,线粒体代谢失调可能是与年龄相关的衰弱的潜在根源。