Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.,Nature Communications

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Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-27 , DOI: 10.1038/s41467-019-14127-9
Efthymia Vokali ₁ , Shann S Yu _{1,

2} , Sachiko Hirosue ₁ , Marcela Rinçon-Restrepo ₁ , Fernanda V Duraes ₃ , Stefanie Scherer ₄ , Patricia Corthésy-Henrioud ₁ , Witold W Kilarski _{1,

2} , Anna Mondino ₅ , Dietmar Zehn ₄ , Stéphanie Hugues ₃ , Melody A Swartz _{1,

2,

6}

Affiliation

Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8+ T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8+ T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.

中文翻译：

在稳态条件下，淋巴内皮细胞将幼稚 CD8+ T 细胞诱导为记忆细胞。

淋巴内皮细胞 (LEC) 化学吸引幼稚 T 细胞并促进其在淋巴结中的存活，并且可以将抗原交叉呈递给幼稚 CD8+ T 细胞以驱动其增殖，尽管缺乏关键的共刺激分子。然而，LEC 启动 CD8+ T 细胞的功能后果尚不清楚。在这里，我们发现，虽然许多增殖的 LEC 教育的 T 细胞进入早期凋亡，但其余的细胞组成了长寿的记忆子集，具有中央记忆和干细胞样记忆 T 细胞的转录、代谢和表型特征。在体内，这些记忆细胞优先归巢于淋巴结，并在记忆回忆后表现出快速增殖和效应分化，并且可以保护小鼠免受随后的细菌感染。这些发现介绍了 LEC 的新免疫调节作用，即直接生成静态但经历过抗原的 CD8+ T 细胞的记忆样子集，这些细胞寿命长，并且在炎症抗原攻击后可以快速分化为效应细胞。

更新日期：2020-01-27

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