Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents.,Scientific Reports

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Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-27 , DOI: 10.1038/s41598-020-58128-x
Simone Kühn _{1,

2} , Anna Mascherek ₁ , Tobias Banaschewski ₃ , Arun L W Bokde ₄ , Christian Büchel ₅ , Erin Burke Quinlan ₆ , Sylvane Desrivières ₆ , Herta Flor _{7,

8} , Antoine Grigis ₉ , Hugh Garavan ₁₀ , Penny Gowland ₁₁ , Andreas Heinz ₁₂ , Bernd Ittermann ₁₃ , Jean-Luc Martinot ₁₄ , Marie-Laure Paillère Martinot ₁₅ , Frauke Nees _{3,

7} , Dimitri Papadopoulos Orfanos ₉ , Tomáš Paus ₁₆ , Luise Poustka _{17,

18} , Sabina Millenet ₃ , Juliane H Fröhner ₁₉ , Michael N Smolka ₁₉ , Henrik Walter ₁₂ , Robert Whelan ₂₀ , Gunter Schumann ₆ , Ulman Lindenberger _{2,

21} , Jürgen Gallinat ₁

Affiliation

University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246, Hamburg, Germany.
Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Department of Psychology, School of Social Sciences, University of Mannheim, 68131, Mannheim, Germany.
NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.
Departments of Psychiatry and Psychology, University of Vermont, 05405, Burlington, Vermont, USA.
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, France.
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France.
Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, M6A 2E1, Canada.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany.
Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom.

Adolescence is a vulnerable time for personality development. Especially neuroticism with its link to the development of psychopathology is of interest concerning influential factors. The present study exploratorily investigates neuroanatomical signatures for developmental trajectories of neuroticism based on a voxel-wise whole-brain structural equation modelling framework. In 1,814 healthy adolescents of the IMAGEN sample, the NEO-FFI was acquired at three measurement occasions across five years. Based on a partial measurement invariance second-order latent growth curve model we conducted whole-brain analyses on structural MRI data at age 14 years, predicting change in neuroticism over time. We observed that a reduced volume in the pituitary gland was associated with the slope of neuroticism over time. However, no relations with prefrontal areas emerged. Both findings are discussed against the background of possible genetic and social influences that may account for this result.

中文翻译：

使用青少年的全脑分析和潜在生长曲线模型，根据基线脑结构预测神经质的变化轨迹。

青春期是个性发展的脆弱时期。特别是与影响精神病理学发展的神经质主义有关影响因素。本研究探索性地研究了基于体素全脑结构方程建模框架的神经质发展轨迹的神经解剖学特征。在IMAGEN样本的1,814名健康青少年中，NEO-FFI是在五年内的三个测量场合中获得的。基于局部测量不变性二阶潜在生长曲线模型，我们对14岁时的结构MRI数据进行了全脑分析，预测了神经质随时间的变化。我们观察到垂体腺体积的减少与神经质倾向随时间的推移有关。然而，没有与前额区的关系出现。在可能导致这一结果的遗传和社会影响的背景下讨论了这两个发现。

更新日期：2020-01-27

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