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A longitudinal study of pupillary light reflex in 6- to 24-month children.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-27 , DOI: 10.1038/s41598-020-58254-6
Clare Kercher 1 , Leila Azinfar 1 , Dinalankara M R Dinalankara 1, 2 , T Nicole Takahashi 3 , Judith H Miles 3 , Gang Yao 1
Affiliation  

Pupillary light reflex (PLR) is an involuntary response where the pupil size changes with luminance. Studies have shown that PLR response was altered in children with autism spectrum disorders (ASDs) and other neurological disorders. However, PLR in infants and toddlers is still understudied. We conducted a longitudinal study to investigate PLR in children of 6-24 months using a remote pupillography device. The participants are categorized into two groups. The 'high risk' (HR) group includes children with one or more siblings diagnosed with ASDs; whereas the 'low risk' (LR) group includes children without an ASD diagnosis in the family history. The participants' PLR was measured every six months until the age of 24 months. The results indicated a significant age effect in multiple PLR parameters including resting pupil radius, minimal pupil radius, relative constriction, latency, and response time. In addition, the HR group had a significantly larger resting and minimal pupil size than the LR group. The experimental data acquired in this study revealed not only general age-related PLR changes in infants and toddlers, but also different PLRs in children with a higher risk of ASD.

中文翻译:


6 至 24 个月儿童瞳孔对光反射的纵向研究。



瞳孔光反射 (PLR) 是一种非自愿反应,其中瞳孔大小随亮度变化。研究表明,患有自闭症谱系障碍 (ASD) 和其他神经系统疾病的儿童的 PLR 反应发生了改变。然而,婴儿和幼儿的 PLR 仍未得到充分研究。我们进行了一项纵向研究,使用远程瞳孔描记设备调查 6-24 个月儿童的 PLR。参与者分为两组。 “高风险”(HR) 组包括一名或多名兄弟姐妹被诊断患有自闭症谱系障碍 (ASD) 的儿童;而“低风险”(LR)组包括家族史中没有 ASD 诊断的儿童。参与者的 PLR 每六个月测量一次,直至 24 个月大。结果表明,年龄对多个 PLR 参数有显着影响,包括静息瞳孔半径、最小瞳孔半径、相对收缩、潜伏期和响应时间。此外,HR 组的静息瞳孔和最小瞳孔尺寸明显大于 LR 组。本研究获得的实验数据不仅揭示了婴儿和幼儿中与年龄相关的一般 PLR 变化,还揭示了自闭症谱系障碍 (ASD) 风险较高的儿童中不同的 PLR。
更新日期:2020-01-27
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