Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2H)‐ones as Potent Antitumor Agents,ChemPlusChem

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Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2H)‐ones as Potent Antitumor Agents
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-01-27 , DOI: 10.1002/cplu.202000008
Mengyao Bian ₁ , Lei Ma ₁ , Min Wu ₁ , Liexin Wu ₁ , Hui Gao ₁ , Wei Yi ₁ , Chao Zhang ₁ , Zhi Zhou ₁

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The cover feature shows a new and efficient rhodium(III)‐catalyzed redox‐neutral C−H activation/ring‐opening of strained ring/[4+2] annulation cascade of N‐methoxybenzamides with propargyl cycloalkanols, providing a direct access to diverse 3‐acyl isoquinolin‐1(2H)‐ones as potential anti‐lung‐cancer drugs. These antitumor agents can powerfully inhibit proliferation and induce apoptosis. More details can be found in the Full Paper by Yi, Zhang, Zhou, and co‐workers (DOI: 10.1002/cplu.201900616).

中文翻译：

Rh（III）催化的氧化还原中性[4 + 2]通告，可直接组装3-酰基异喹啉-1（2H）-酮作为有效的抗肿瘤剂

掩盖特征显示了新型高效的铑（III）催化的氧化还原中性C-H活化/ N-甲氧基苯甲酰胺与炔丙基环烷醇的应变环/ [4 + 2]环合级联的开环，可直接访问各种3-酰基异喹啉-1（2 H）-一种潜在的抗肺癌药物。这些抗肿瘤剂可有效抑制增殖并诱导凋亡。可以在Yi，Zhang，Zhou和同事的论文全文中找到更多详细信息（DOI：10.1002 / cplu.201900616）。

更新日期：2020-01-27

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