Supplemental Digital Content is available in the text. Blood pressure (BP) is a leading global risk factor. Increasing age is related to changes in cardiovascular physiology that could influence cuff BP measurement, but this has never been examined systematically and was the aim of this study. Cuff BP was compared with invasive aortic BP across decades of age (from 40 to 89 years) using individual-level data from 31 studies (1674 patients undergoing coronary angiography) and 22 different cuff BP devices (19 oscillometric, 1 automated auscultation, 2 mercury sphygmomanometry) from the Invasive Blood Pressure Consortium. Subjects were aged 64±11 years, and 32% female. Cuff systolic BP overestimated invasive aortic systolic BP in those aged 40 to 49 years, but with each older decade of age, there was a progressive shift toward increasing underestimation of aortic systolic BP (P<0.0001). Conversely, cuff diastolic BP overestimated invasive aortic diastolic BP, and this progressively increased with increasing age (P<0.0001). Thus, there was a progressive increase in cuff pulse pressure underestimation of invasive aortic PP with increasing decades of age (P<0.0001). These age-related trends were observed across all categories of BP control. We conclude that cuff BP as an estimate of aortic BP was substantially influenced by increasing age, thus potentially exposing older people to greater chance for misdiagnosis of the true risk related to BP.

中文翻译：

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年龄对上臂袖带血压测量的影响

文本中提供了补充数字内容。血压（BP）是全球主要的危险因素。年龄的增长与心血管生理学的变化有关，心血管生理学的变化可能会影响袖带血压测量，但这一点从未得到系统的检验，也是本研究的目的。使用来自 31 项研究（1674 名接受冠状动脉造影的患者）和 22 种不同袖带血压设备（19 种示波法、1 种自动听诊法、2 种水银汞柱）的个人数据，将袖带血压与数十年年龄（从 40 岁至 89 岁）的侵入性主动脉血压进行比较。血压测量法）来自有创血压协会。受试者年龄为 64±11 岁，其中 32% 为女性。在 40 至 49 岁的人群中，袖带收缩压高估了有创主动脉收缩压，但随着年龄的增长，主动脉收缩压逐渐被低估（P<0.0001）。相反，袖带舒张压高估了侵入性主动脉舒张压，并且随着年龄的增长而逐渐增加（P<0.0001）。因此，随着年龄的增长，袖带脉压对侵入性主动脉 PP 的低估逐渐增加（P<0.0001）。在所有类别的血压控制中都观察到了这些与年龄相关的趋势。我们得出的结论是，袖带血压作为主动脉血压的估计值很大程度上受到年龄增长的影响，因此老年人可能更容易误诊与血压相关的真实风险。