Supplemental Digital Content is available in the text. Angiogenic markers such as PlGF (placental growth factor) and sFlt-1 (soluble Fms-like tyrosine kinase-1) have been shown to be useful for predicting adverse outcome in women suspected of having preeclampsia. The aim of the current study was to evaluate the prognostic value of angiogenic markers and maternal risk factors in pregnant women with hypertension. This was a prospective study of pregnancies complicated by preeclampsia, gestational hypertension, or chronic hypertension presenting to 1 of 2 tertiary referral hospitals between May 2013 and May 2018. Maternal characteristics along with blood samples for angiogenic marker analysis were obtained from participants. The primary outcome was delivery related to preeclampsia within 1 and 2 weeks. In total, 302 women with hypertension were included in the study cohort. The baseline model included maternal body mass index, mean arterial pressure, and clinical diagnosis at the time of assessment. The use of sFlt-1/PIGF ratio combined with the baseline model significantly improved the area under the curve values for predicting delivery within a week (0.83 versus 0.88; P=0.025) or in 2 weeks (0.86 versus 0.93; P=0.001) due to preeclampsia-related events in gestational ages <35 weeks. The magnitude of increase in accuracy was 7.9% (−0.5% to 16.4%, posterior probability of increase: 96.7%) for sFlt-1/PlGF ratio. Our results emphasize the additive value of angiogenic biomarkers and the superior performance of a continuous scale of sFlt-1/PlGF ratio in the model. The added utility of angiogenic markers diminishes after 35 weeks’ gestation.

中文翻译：

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高血压孕妇的血管生成标志物预后模型

补充数字内容在文本中可用。血管生成标志物如 PlGF（胎盘生长因子）和 sFlt-1（可溶性 Fms 样酪氨酸激酶-1）已被证明可用于预测怀疑患有先兆子痫的女性的不良结果。本研究的目的是评估血管生成标志物和孕妇危险因素对高血压孕妇的预后价值。这是一项前瞻性研究，研究对象是 2013 年 5 月至 2018 年 5 月期间在 2 家三级转诊医院中的一家出现并发先兆子痫、妊娠高血压或慢性高血压的妊娠。从参与者那里获得了母亲特征以及用于血管生成标志物分析的血液样本。主要结果是在 1 周和 2 周内与先兆子痫相关的分娩。总共，研究队列中包括 302 名患有高血压的女性。基线模型包括评估时的母亲体重指数、平均动脉压和临床诊断。使用 sFlt-1/PIGF 比率结合基线模型显着改善了预测一周内（0.83 对 0.88；P=0.025）或两周内（0.86 对 0.93；P=0.001）分娩的曲线下面积值由于胎龄<35周的先兆子痫相关事件。sFlt-1/PlGF 比值的准确度增加幅度为 7.9%（-0.5% 至 16.4%，增加的后验概率：96.7%）。我们的结果强调了血管生成生物标志物的附加价值和模型中 sFlt-1/PlGF 比值的连续尺度的优越性能。妊娠 35 周后血管生成标志物的附加效用减弱。