A multiresidue method optimization was conducted using the design of experiment approach. Out of 43 tested organophosphate compounds, 27 could be validated in surface water, yielding limits of detection of 0.6 to 2.5 ng L −1 by dispersive liquid‐liquid micro‐extraction and subsequent liquid chromatography‐tandem quadrupole mass spectrometry (LC‐MSMS) detection. For the optimization of the sample preparation, the factors sonication time, sample volume, binary extraction ratio, and addition of salt have been investigated by the Taguchi design of experiment approach. One hundred fifty milliliters sample were extracted for 1 minute with 400 μ L acetone and 800 μ L tetrachloroethene (TCE) three times subsequently. No salts were added. Combined extracts were reconstituted in 65 μ L methanol, ready for analysis.

中文翻译：

---

地表水中有机磷农药的分析——方法优化方法的比较

使用实验方法设计进行了多残留方法优化。在 43 种测试的有机磷酸盐化合物中，有 27 种可以在地表水中得到验证，通过分散液-液微萃取和随后的液相色谱-串联四极杆质谱 (LC-MSMS) 检测，检测限为 0.6 至 2.5 ng L -1 . 为了优化样品制备，通过田口实验设计方法研究了超声处理时间、样品体积、二元提取率和盐的添加等因素。随后用 400 μL 丙酮和 800 μL 四氯乙烯 (TCE) 提取 150 毫升样品 1 分钟 3 次。没有添加盐。合并的提取物在 65 μL 甲醇中复溶，准备用于分析。