Bioactive Pore-Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing.,Advanced Materials

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Bioactive Pore-Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-01-27 , DOI: 10.1002/adma.201907491
Liju Xu _{1,

2} , Shan Gao ₃ , Rubing Zhou ₃ , Fang Zhou ₃ , Yan Qiao _{1,

2} , Dong Qiu _{1,

2}

Affiliation

The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore-forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass-involved macropore-embedded bone adhesives is developed, which is capable of facilitating the migration of bone-derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass-particle-encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell-ingrowth efficacy.

中文翻译：

具有生物活性的毛孔形成骨粘合剂，可促进细胞向内生长，促进骨折愈合。

已知商业骨粘合剂的有效性由于细胞向内生长的弱功效而受到阻碍。大孔形成的策略，特别是具有生物活性的大孔，具有解决这一问题的巨大希望，从而促进骨折愈合。在此，开发了一类生物活性的涉及玻璃的大孔包埋的骨粘合剂，其能够促进骨来源的间充质基质细胞向粘合剂层的迁移并向骨细胞的分化。将生物活性玻璃颗粒包裹的致孔剂整合到骨粘合剂中是这种方法的关键。观察到在骨粘合剂上的牢固的即时粘合和在小鼠颅骨上的骨再生的高效率，这两者对于临床应用和个性化手术程序都是至关重要的。

更新日期：2020-03-09

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