Autophagy is a cellular stress response mechanism activation of which leads to degradation of cellular components, including proteins as well as damaged organelles in lysosomes. Defects in autophagy mechanisms were associated with several pathologies (e.g. cancer, neurodegenerative diseases, and rare genetic diseases). Therefore, autophagy regulation is under strict control. Transcriptional and post-translational mechanisms that control autophagy in cells and organisms studied in detail. Recent studies introduced non-coding small RNAs, and especially microRNAs (miRNAs) in the post-translational orchestration of the autophagic activity. In this review article, we analyzed in detail the current status of autophagy-miRNA connections. Comprehensive documentation of miRNAs that were directly involved in autophagy regulation resulted in the emergence of common themes and concepts governing these complex and intricate interactions. Hence, a better and systematic understanding of these interactions reveals a central role for miRNAs in the regulation of autophagy.

中文翻译：

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MicroRNA作为自噬途径的主要调节剂。

自噬是细胞应激反应机制的激活，其激活导致细胞组分的降解，包括蛋白质以及溶酶体中受损的细胞器。自噬机制的缺陷与几种病理学有关（例如，癌症，神经退行性疾病和罕见的遗传性疾病）。因此，自噬调节受到严格控制。详细研究了控制细胞和生物中自噬的转录和翻译后机制。最近的研究在自噬活性的翻译后编排中引入了非编码小RNA，尤其是microRNA（miRNA）。在这篇评论文章中，我们详细分析了自噬miRNA连接的当前状态。直接参与自噬调节的miRNA的全面记录导致出现了共同的主题和概念，这些主题和概念主导着这些复杂而复杂的相互作用。因此，对这些相互作用的更好和系统的了解揭示了miRNA在自噬调节中的核心作用。